Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50012916
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50561585(CHEMBL4788047)
Affinity DataIC50: 440nMAssay Description:Inhibition of human C-terminal His-tagged SIRT2 (50 to 356 residues) expressed in Escherichia coli using Ac-Gln-Pro-Lys-Lys(pro)-AMC (oxo-11) as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50561584(CHEMBL4741089)
Affinity DataIC50: 510nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged SIRT1 (193 to 741 residues) expressed in Escherichia coli using Ac-Gln-Pro-Lys-Lys(Ac)-AMC (oxo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50561585(CHEMBL4788047)
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged SIRT1 (193 to 741 residues) expressed in Escherichia coli using Ac-Gln-Pro-Lys-Lys(Ac)-AMC (oxo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50561586(CHEMBL4788926)
Affinity DataIC50: 980nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged SIRT1 (193 to 741 residues) expressed in Escherichia coli using Ac-Gln-Pro-Lys-Lys(Ac)-AMC (oxo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50561588(CHEMBL4776939)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged SIRT1 (193 to 741 residues) expressed in Escherichia coli using Ac-Gln-Pro-Lys-Lys(Ac)-AMC (oxo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50561588(CHEMBL4776939)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human C-terminal His-tagged SIRT2 (50 to 356 residues) expressed in Escherichia coli using Ac-Gln-Pro-Lys-Lys(pro)-AMC (oxo-11) as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50561587(CHEMBL4759512)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged SIRT1 (193 to 741 residues) expressed in Escherichia coli using Ac-Gln-Pro-Lys-Lys(Ac)-AMC (oxo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50561584(CHEMBL4741089)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human C-terminal His-tagged SIRT2 (50 to 356 residues) expressed in Escherichia coli using Ac-Gln-Pro-Lys-Lys(pro)-AMC (oxo-11) as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50300464((S)-benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli in presence of acyl peptide acetyl-H3K9 as substrate incubated for 5 mins by HPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50561589(CHEMBL4744968)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli in presence of acyl peptide acetyl-H3K9 as substrate incubated for 5 mins by HPLC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed