Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50012838
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 35nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human PDE10A catalytic domain (449 to 770 residues) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human PDE10A catalytic domain (449 to 770 residues) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE11A catalytic domain (unknown origin) using [3H]-cAMP or [3H]-GAMP as substrate after 15 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE7A1 catalytic domain (130 to 482 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation count...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human PDE1B (10-487 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation countin...More data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE11A catalytic domain (unknown origin) using [3H]-cAMP or [3H]-GAMP as substrate after 15 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PDE8A1 catalytic domain (480 to 820 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation count...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PDE3A catalytic domain (679 to 1087 residues) (unknown origin) using 3H-cAMP as substrate after 15 mins by liquid scintillation countin...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) using [3H]cAMP as substrate after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PDE2A catalytic domain (580 to 941 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDE3A catalytic domain (679 to 1087 residues) (unknown origin) using 3H-cAMP as substrate after 15 mins by liquid scintillation countin...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintil...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE1B (10-487 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation countin...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDE2A catalytic domain (580 to 941 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDE8A1 catalytic domain (480 to 820 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation count...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) using [3H]cAMP as substrate after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDE7A1 catalytic domain (130 to 482 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation count...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting...More data for this Ligand-Target Pair
