Compile Data Set for Download or QSAR
Report error Found 72 Enz. Inhib. hit(s) with all data for entry = 50011062
TargetBromodomain-containing protein 2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd: >3.00E+5nMAssay Description:Binding affinity to BRD2 BD2 (unknown origin) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd: >3.00E+5nMAssay Description:Binding affinity to BRD3 BD2 (unknown origin) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd: >3.00E+5nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to BRD2 BD1 (unknown origin) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to BRD3 BD1 (unknown origin) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataKd:  1.26E+3nMAssay Description:Binding affinity to BRD4 BD2 (333 to 460 residues) (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataKd:  10nMAssay Description:Binding affinity to N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escherichia coli by surface plasmon reson...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 10nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 10nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 13nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD1 (1 to 473 residues)/BD2 Y386A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 16nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD2 (1 to 435 residues)/BD1 Y73A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 25nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRDT BD1 (1 to 397 residues)/BD2 Y309A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50: 25nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50: 32nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50: 40nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 40nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD2 (1 to 473 residues)/BD1 Y113A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 40nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50: 40nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50: 50nMAssay Description:Displacement of bromosporine-tracer from BRD4 (unknown origin) expressed in HEK293 cells by NanoBRET NanoGlo substrate based NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50: 50nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD1 (1 to 473 residues)/BD2 Y386A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544603(CHEMBL4633643)
Affinity DataIC50: 50nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50: 79nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD1 (1 to 473 residues)/BD2 Y386A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50: 79nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD2 (1 to 435 residues)/BD1 Y73A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544611(CHEMBL4639924)
Affinity DataIC50: 79nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50: 126nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRDT BD1 (1 to 397 residues)/BD2 Y309A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50: 158nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRDT BD1 (1 to 397 residues)/BD2 Y309A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50: 200nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD2 (1 to 473 residues)/BD1 Y113A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544612(CHEMBL4640166)
Affinity DataIC50: 251nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50: 316nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRDT BD2 (1 to 397 residues)/BD1 Y66A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50: 316nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544603(CHEMBL4633643)
Affinity DataIC50: 501nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544599(CHEMBL4635126)
Affinity DataIC50: 501nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544607(CHEMBL4641363)
Affinity DataIC50: 501nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544600(CHEMBL4641414)
Affinity DataIC50: 631nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544608(CHEMBL4642291)
Affinity DataIC50: 794nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544606(CHEMBL4644512)
Affinity DataIC50: 794nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544598(CHEMBL4648188)
Affinity DataIC50: 794nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544614(CHEMBL4643720)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544615(CHEMBL4633358)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD2 (1 to 435 residues)/BD1 Y73A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544610(CHEMBL4635194)
Affinity DataIC50: 1.26E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544602(CHEMBL4640928)
Affinity DataIC50: 1.26E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50: 1.59E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRDT BD2 (1 to 397 residues)/BD1 Y66A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544601(CHEMBL4637861)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544613(CHEMBL4646732)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50: 3.16E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD2 (1 to 473 residues)/BD1 Y113A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544611(CHEMBL4639924)
Affinity DataIC50: 3.16E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544598(CHEMBL4648188)
Affinity DataIC50: 3.16E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50: 6.31E+3nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant expressed in Escheri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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