Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50012248
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human recombinant PDE4D using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human recombinant PDE4A using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant PDE4C using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555898(CHEMBL3182164)
Affinity DataIC50: 3nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 13nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 67nMAssay Description:Inhibition of PDE4A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 79nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 120nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 160nMAssay Description:Inhibition of PDE4A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 220nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555898(CHEMBL3182164)
Affinity DataIC50: 287nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555898(CHEMBL3182164)
Affinity DataIC50: 310nMAssay Description:Inhibition of PDE4A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555896(CHEMBL4746166)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555897(CHEMBL4762291)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant PDE4C using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of PDE4C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555897(CHEMBL4762291)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant PDE4B1 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555898(CHEMBL3182164)
Affinity DataIC50: 3.86E+3nMAssay Description:Inhibition of PDE4C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555897(CHEMBL4762291)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of PDE4C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555894(CHEMBL4748353)
Affinity DataIC50: 2.08E+4nMAssay Description:Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50555895(CHEMBL4785640)
Affinity DataIC50: 3.53E+4nMAssay Description:Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed