Compile Data Set for Download or QSAR
Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 50018331
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422753(CHEMBL5282138)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to human FLT3 assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) phosphorylation in mouse BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM144315(US8969336, 577 | US8969336, 547 | Gilteritinib | U...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM144315(US8969336, 577 | US8969336, 547 | Gilteritinib | U...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of FLT3 D835H mutant (unknown origin) phosphorylation in mouse BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422751(Denfivontinib | G-749 | DENFIVONTINIB)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FLT3 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Aurora-A (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422749(CHEMBL5287891)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422752(CHEMBL5284731)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FLT3-ITD mutant phosphorylation in human MOLM-14 cell incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50056199(CHEMBL3329684)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50380950(CHEMBL2016905)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422751(Denfivontinib | G-749 | DENFIVONTINIB)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of FLT3-D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50601438(CHEMBL5170277)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin) expressed in mouse BaF3 cells assessed as inhibitionMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human SEMK2 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50380974(CHEMBL2016903)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM350864(US9795606, B25 | UNC1666A | US10004755, Compound U...)
Affinity DataIC50: 3nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422748(CHEMBL5269280)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM144315(US8969336, 577 | US8969336, 547 | Gilteritinib | U...)
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human SEMK2 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422745(CHEMBL4066041)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422748(CHEMBL5269280)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50601438(CHEMBL5170277)
Affinity DataIC50: 9nMAssay Description:Inhibition of FLT3 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50250180(CHEMBL4101411)
Affinity DataIC50: 9nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50162967(CHEMBL3792850)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of FLT3 D835H mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422746(CHEMBL5274495)
Affinity DataIC50: 15nMAssay Description:Inhibition of Aurora-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50193118(CHEMBL3904118)
Affinity DataIC50: 16nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422752(CHEMBL5284731)
Affinity DataIC50: 17nMAssay Description:Inhibition of FLT3-D835Y mutant phosphorylation in human MOLM-14 cell incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 20nMAssay Description:Inhibition of FLT3-ITD mutant phosphorylation in human HEK-293T cells incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50193118(CHEMBL3904118)
Affinity DataIC50: 21nMAssay Description:Inhibition of FLT3-D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50135187(CHEMBL3745919 | US10266535, Compound 22)
Affinity DataIC50: 40nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 50nMAssay Description:Inhibition of FLT3-ITD mutant phosphorylation in human MV4-11 cell incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 58nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422746(CHEMBL5274495)
Affinity DataIC50: 67nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 67nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422747(CHEMBL5283098)
Affinity DataIC50: 71nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase B(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 78nMAssay Description:Inhibition of Aurora-B (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50250180(CHEMBL4101411)
Affinity DataIC50: 91nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422750(CHEMBL5268237)
Affinity DataIC50: 100nMAssay Description:Inhibition of FLT3 (unknown origin) autophosphorylation expressed in human Leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 118nMAssay Description:Inhibition of Aurora-A (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 250nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human RS4-11 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human RS4-11 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50277608(CHEMBL4173067)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to human FLT3 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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