Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50011299
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Binding affinity to 15N-labeled human CFD by 1H-15N-HSQC NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546245(CHEMBL4101312)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to human CFD at 100 uM by WaterLOGSY NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546248(CHEMBL3185765)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of ROCK2 (unknown origin) using histone as substrate incubated for 20 mins in presence of [gamma32P]-ATP by liquid scintillation counter m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546243(CHEMBL4753864)
Affinity DataIC50: 6nMAssay Description:Inhibition of CFD in 10% human serum assessed as reduction in alternate complement pathway-mediated hemolysis incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal GST-fused human ROCK2 catalytic domain ( 1 to 553 residues) expressed in baculovirus expression system using Long S6 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50201565(CHEMBL3941259)
Affinity DataIC50: 50nMAssay Description:Inhibition of CFD in 50% human whole blood assessed as reduction in alternate complement pathway-mediated MAC formation pre-incubated for 15 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of N-terminal GST-fused human ROCK1 catalytic domain ( 1 to 477 residues) expressed in baculovirus expression system using Long S6 Kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546243(CHEMBL4753864)
Affinity DataIC50: 70nMAssay Description:Inhibition of CFD in human RBC model of anti-CD55/anti-CD59-induced paroxysmal nocturnal hemoglobinuria assessed as reduction in complement fragment ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546243(CHEMBL4753864)
Affinity DataIC50: 140nMAssay Description:Inhibition of CFD in 50% human whole blood assessed as reduction in alternate complement pathway-mediated MAC formation pre-incubated for 15 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement C5(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546241(CHEMBL2203296)
Affinity DataIC50: 210nMAssay Description:Inhibition of C5 complement protein in 2% human serum incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 260nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 320nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement C5(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546240(CHEMBL2204196)
Affinity DataIC50: 440nMAssay Description:Inhibition of C5 complement protein in 2% human serum incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement C5(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546242(CHEMBL4756677)
Affinity DataIC50: 620nMAssay Description:Inhibition of C5 complement protein in 2% human serum incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM203868((S)-N2-benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrro...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human CFD catalytic domain (G24 to A253 residues) expressed in Escherichia coli (Rosetta) using Z-Lys-thiobenzyl and 2,4-di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant human CFD catalytic domain (G24 to A253 residues) expressed in Escherichia coli (Rosetta) using Z-Lys-thiobenzyl and 2,4-di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM203864((S)-N2-(4-methoxyphenethyl)-N1-(naphthalen-1-ylmet...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human CFD catalytic domain (G24 to A253 residues) expressed in Escherichia coli (Rosetta) using Z-Lys-thiobenzyl and 2,4-di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546244(CHEMBL4757532)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of LPS/IFN-gamma induced NO-dependent iNOS activity in mouse RAW 264.7 cells incubated for 16 hrs by Griess reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human ROCK2 expressed in baculovirus expression system by Kinase-Glo luminescent AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human ROCK1 expressed in baculovirus expression system by Kinase-Glo luminescent AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM97464(US8609833, 17 | US8470800, A | US8609833, 86)
Affinity DataKi:  0.970nMAssay Description:Binding affinity to A1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to A3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546247(Netarsudil | AR-11324 FREE BASE | AR-13324 | US114...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of human ROCK2 by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed