Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50018481
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM18049(3-({[(4-{[(carbamimidamidomethanimidoyl)sulfanyl]m...)
Affinity DataKd:  13nMAssay Description:Inhibition of Escherichia coli DHFR in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608613(CHEMBL5291432)
Affinity DataKd:  3.20E+3nMAssay Description:Inhibition of Escherichia coli DHFR in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608610(CHEMBL5279457)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50335530((S)-3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-d...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of wild type Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608612(CHEMBL1904209)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant Mycobacterium tuberculosis DHFR using dihydrofolate as substrate preincubated for 1 min followed by substrate addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50536186(CHEMBL4483572)
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608617(CHEMBL5284400)
Affinity DataIC50: 18nMAssay Description:Inhibition of wild type Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608609(TCMDC-124259 | CHEMBL586115)
Affinity DataIC50: 22nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50536188(CHEMBL4532935)
Affinity DataIC50: 39nMAssay Description:Inhibition of Escherichia coli DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM210930(UCP1173)
Affinity DataIC50: 177nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608614(CHEMBL1724189)
Affinity DataIC50: 189nMAssay Description:Inhibition of Escherichia coli DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50536188(CHEMBL4532935)
Affinity DataIC50: 366nMAssay Description:Inhibition of Escherichia coli DfrA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM210931(UCP1175)
Affinity DataIC50: 460nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608620(CHEMBL5273280)
Affinity DataIC50: 460nMAssay Description:Inhibition of Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608622(CHEMBL5276327)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608621(CHEMBL5289313)
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608619(CHEMBL5281143)
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608611(CHEMBL4436643)
Affinity DataIC50: 2.46E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608615(CHEBI:34383 | CHEMBL1162149)
Affinity DataIC50: 3.23E+4nMAssay Description:Inhibition of Escherichia coli DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50119764(CHEMBL3616528)
Affinity DataIC50: 3.86E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608618(CHEMBL5283880)
Affinity DataIC50: 4.15E+4nMAssay Description:Inhibition of wild type Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50019166(CHEMBL336718)
Affinity DataIC50: 4.91E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataIC50: 9.57E+4nMAssay Description:Inhibition of Escherichia coli DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM210929(UCP1172)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Escherichia coli DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608616(CHEMBL5287382)
Affinity DataKi:  4nMAssay Description:Inhibition of wild type Staphylococcus aureus DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608614(CHEMBL1724189)
Affinity DataKi:  7.80nMAssay Description:Inhibition of Escherichia coli DHFR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataKi:  3.15E+4nMAssay Description:Inhibition of Escherichia coli DHFR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50608615(CHEBI:34383 | CHEMBL1162149)
Affinity DataKi:  3.59E+4nMAssay Description:Inhibition of Escherichia coli DHFR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed