Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50009357
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527899(CHEMBL4475041)
Affinity DataEC50:  81nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527904(CHEMBL4541134)
Affinity DataKd:  1.23E+3nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527899(CHEMBL4475041)
Affinity DataKd:  11nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527904(CHEMBL4541134)
Affinity DataEC50:  8.71E+4nMAssay Description:Partial agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataKd:  1.40nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527903(CHEMBL4530245)
Affinity DataEC50:  1.05E+5nMAssay Description:Partial agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527902(CHEMBL4555037)
Affinity DataEC50:  2.95E+3nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527903(CHEMBL4530245)
Affinity DataKd:  550nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527899(CHEMBL4475041)
Affinity DataKd:  11nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataEC50:  126nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527899(CHEMBL4475041)
Affinity DataEC50:  80nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataEC50:  126nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527902(CHEMBL4555037)
Affinity DataEC50:  2.96E+3nMAssay Description:Agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by Mag-Fluo4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527904(CHEMBL4541134)
Affinity DataEC50:  8.77E+4nMAssay Description:Partial agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527903(CHEMBL4530245)
Affinity DataEC50:  1.04E+5nMAssay Description:Partial agonist activity at rat IP3R1 expressed in HEK cells assessed as increase in calcium release in cytosol by measuring fluorescence signal by M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataKd:  8.70nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527904(CHEMBL4541134)
Affinity DataKd:  1.23E+3nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527903(CHEMBL4530245)
Affinity DataKd:  549nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527902(CHEMBL4555037)
Affinity DataKd:  129nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527902(CHEMBL4555037)
Affinity DataKd:  129nMAssay Description:Displacement of [3H]-IP3 from IP3R1 in Wistar rat cerebellar membrane measured after 5 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527901(CHEMBL4514897)
Affinity DataKd:  0nMAssay Description:Specific binding of [3H]-Ins(1,4,5)P3 to IP3R1 in Wistar rat cerebellar membrane at 30 uM measured after 5 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50527900(CHEMBL4445052)
Affinity DataKd:  0nMAssay Description:Specific binding of [3H]-Ins(1,4,5)P3 to IP3R1 in Wistar rat cerebellar membrane at 30 uM measured after 5 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed