Compile Data Set for Download or QSAR
Report error Found 79 Enz. Inhib. hit(s) with all data for entry = 50018729
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 0.400nMAssay Description:Competitive inhibition of JAK2 (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-...)
Affinity DataIC50: 0.480nMAssay Description:Competitive inhibition of JAK2 (unknown origin) in the presence of ATP by JAK radiometric filter binding kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of full length JAK2 V617F mutant (unknown origin) by JAK radiometric filter binding kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-...)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of full length wild type JAK2 (unknown origin) by JAK radiometric filter binding kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of human JAK2 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50611956(CHEMBL2367481)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of wild-type JAK2 (unknown origin) expressed in baculovirus expression system using (biotinyl-amino-hexanoyl)EQEDEPEGDYFEWLE-amide as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal flag tagged human JAK2 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal flag tagged human TYK2 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 1.30nMAssay Description:Competitive inhibition of JAK1 (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50611957(CHEMBL5282343)
Affinity DataIC50: 2nMAssay Description:Inhibition of JAK2 (unknown origin) by Lanthascreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM246868({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human JAK2 (808 to end residues) in the presence of [gamma p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human JAK1 (850 to end residues) in the presence of [gamma p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50611956(CHEMBL2367481)
Affinity DataIC50: 3nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 (unknown origin) by Lanthascreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal flag tagged human JAK3 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11643396, Example TG101209 | US112797...)
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50611957(CHEMBL5282343)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK3 (unknown origin) by Lanthascreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM128101(US8796457, 1 | US9505754, 1 | US10206907, Compound...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50611955(OCLACITINIB | Oclacitinib | JAK-I | JAKI | PF 0339...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human JAK1 (852 to 1142 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-...)
Affinity DataIC50: 11nMAssay Description:Competitive inhibition of TYK2 (unknown origin) in the presence of ATP by JAK radiometric filter binding kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant GST-tagged JAK1 (unknown origin) expressed in baculovirus infected Sf9 cells in the presence of ATP by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human JAK3 (781 to end residues) in the presence of [gamma p33]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal flag tagged mouse JAK1 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11643396, Example TG101209 | US112797...)
Affinity DataIC50: 17nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50611955(OCLACITINIB | Oclacitinib | JAK-I | JAKI | PF 0339...)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human JAK2 (808 to 1132 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 18nMAssay Description:Inhibition of IFN-alpha induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IFN-alpha stimulation and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant GST-tagged JAK2 (unknown origin) expressed in baculovirus infected Sf9 cells in the presence of ATP by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-...)
Affinity DataIC50: 19nMAssay Description:Competitive inhibition of JAK3 (unknown origin) in the presence of ATP by JAK radiometric filter binding kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 20nMAssay Description:Inhibition of IL-23 stimulated STAT3 production in human naive T cell preincubated with compound for 10 to 15 mins followed by IL-23 stimulation and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 22nMAssay Description:Inhibition of human TYK2 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11643396, Example TG101209 | US112797...)
Affinity DataIC50: 25nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50611956(CHEMBL2367481)
Affinity DataIC50: 25nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-...)
Affinity DataIC50: 32nMAssay Description:Competitive inhibition of JAK1 (unknown origin) in the presence of ATP by JAK radiometric filter binding kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 33nMAssay Description:Inhibition of IL-6 induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IL-6 stimulation and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 33nMAssay Description:Inhibition of human JAK1 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
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