Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50007948
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50514308(CHEMBL4448899)
Affinity DataIC50: 2nMAssay Description:Inhibition of human GLUT1 expressed in DLD1 cells assessed as glucose uptake by measuring ATP incubated for 15 mins by CellTiter-Glo Luminescent Cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50149871((R)-2-((3-(biphenyl-4-yloxy)-3-(4-fluorophenyl)pro...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human GlyT1 expressed in QT6 cells assessed as reduction in [14C]glycine uptake incubated for 20 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50102692(ORG-25543 | 4-Benzyloxy-N-(1-dimethylamino-cyclope...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human GlyT2 stably expressed in CHO cells assessed as reduction in [3H]glycine uptake incubated for 10 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 17nMAssay Description:Inhibition of EAAT2 (unknown origin) transiently expressed in COS1 cells by [14C]glutamate based uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 22nMAssay Description:Inhibition of EAAT1 (unknown origin) transiently expressed in COS1 cells by [14C]glutamate based uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human URAT1 expressed in HEK293T cells by assessed as [14C]urate uptake preincubated for 5 mins followed by [14C]urate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human URAT1 expressed in Xenopus oocytes by [14C]urate uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium- and chloride-dependent glycine transporter 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50149856({Methyl-[(R)-3-phenyl-3-(4-trifluoromethyl-phenoxy...)
Affinity DataIC50: 126nMAssay Description:Inhibition of GlyT1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM20875(CHEMBL245067 | JMC511145 Compound 1 | 1-(2,4-dihyd...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human SGLT2 expressed in Xenopus oocytes assessed as reduction in [14C]AMG uptake after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetExcitatory amino acid transporter 3(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 300nMAssay Description:Inhibition of EAAT3 (unknown origin) transiently expressed in COS1 cells by [14C]glutamate based uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetExcitatory amino acid transporter 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50292997(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Affinity DataIC50: 660nMAssay Description:Inhibition of EAAT1 (unknown origin) stably expressed in HEK293 cells assessed as reduction in [14C]glutamate uptake incubated for 5 mins by microbet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 11(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of human OAT4 expressed in HEK293 cells by assessed as [14C]urate uptake preincubated for 5 mins followed by [14C]urate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)
Affinity DataIC50: 3.53E+3nMAssay Description:Inhibition of human URAT1 expressed in HEK293T cells by assessed as [14C]urate uptake preincubated for 5 mins followed by [14C]urate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of [3H]-DHTBZ binding to VMAT2 from rat forebrain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed