Compile Data Set for Download or QSAR
Report error Found 74 Enz. Inhib. hit(s) with all data for entry = 50008468
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519568(CHEMBL4549822)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519570(CHEMBL4567083)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519585(CHEMBL4464773)
Affinity DataIC50: 0.381nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519591(CHEMBL4562583)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519574(CHEMBL4563433)
Affinity DataIC50: 0.626nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519588(CHEMBL4584584)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519580(CHEMBL4574439)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519565(CHEMBL4441362)
Affinity DataIC50: 0.758nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519567(CHEMBL4476024)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519571(CHEMBL4454609)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519595(CHEMBL4545014)
Affinity DataIC50: 2nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519569(CHEMBL4545950)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519585(CHEMBL4464773)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519582(CHEMBL4525972)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519570(CHEMBL4567083)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519587(CHEMBL4467942)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519568(CHEMBL4549822)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519590(CHEMBL4574370)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519592(CHEMBL4442047)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519579(CHEMBL4576647)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519575(CHEMBL4567339)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519574(CHEMBL4563433)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519586(CHEMBL4439499)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519580(CHEMBL4574439)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519577(CHEMBL4439148)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519571(CHEMBL4454609)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519578(CHEMBL4445815)
Affinity DataIC50: 12nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519589(CHEMBL4531985)
Affinity DataIC50: 13nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519566(CHEMBL4565208)
Affinity DataIC50: 14nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519569(CHEMBL4545950)
Affinity DataIC50: 14nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519591(CHEMBL4562583)
Affinity DataIC50: 16nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519573(CHEMBL4456770)
Affinity DataIC50: 16nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519567(CHEMBL4476024)
Affinity DataIC50: 17nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519590(CHEMBL4574370)
Affinity DataIC50: 21nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519593(CHEMBL4465323)
Affinity DataIC50: 24nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519565(CHEMBL4441362)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged LTC4S expressed in in Pichia pastoris X33 assessed as inhibition of EXC4 formation using EXA4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519565(CHEMBL4441362)
Affinity DataIC50: 27nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519583(CHEMBL4440468)
Affinity DataIC50: 27nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519595(CHEMBL4545014)
Affinity DataIC50: 28nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519592(CHEMBL4442047)
Affinity DataIC50: 28nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519588(CHEMBL4584584)
Affinity DataIC50: 31nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519576(CHEMBL4466708)
Affinity DataIC50: 32nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519587(CHEMBL4467942)
Affinity DataIC50: 34nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Orexo

Curated by ChEMBL
LigandPNGBDBM50519581(CHEMBL4460916)
Affinity DataIC50: 35nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
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