Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50008234
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50516943(CHEMBL332610)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50516942(NSC-381281 | CHEMBL119576)
Affinity DataIC50: 70nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 240nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50516943(CHEMBL332610)
Affinity DataIC50: 320nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 530nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM23928(CHEMBL296411 | 1,3-dimethoxy-5-[(E)-2-(4-methoxyph...)
Affinity DataIC50: 760nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50516942(NSC-381281 | CHEMBL119576)
Affinity DataIC50: 780nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM23928(CHEMBL296411 | 1,3-dimethoxy-5-[(E)-2-(4-methoxyph...)
Affinity DataIC50: 3.62E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50131688(4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-phenol | Pteros...)
Affinity DataIC50: 3.91E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50332182(4,3',5'-tri-O-methylpiceatannol | 5-(2-(3,5-Dimeth...)
Affinity DataIC50: 5.48E+3nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50332182(4,3',5'-tri-O-methylpiceatannol | 5-(2-(3,5-Dimeth...)
Affinity DataIC50: 5.49E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed