Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50007771
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM329334((2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(met...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-AhxPWDPDDADITEILG-NH2 as substrate preincubated for 15 mins followed by substrate addition by TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM258444(US9512130, 2)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-AhxPWDPDDADITEILG-NH2 as substrate preincubated for 15 mins followed by substrate addition by TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50072911(CHEMBL3410084)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of MPS1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50512459(CHEMBL4581793)
Affinity DataIC50: 1nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50072900(CHEMBL3410073)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of MPS1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50386816(CHEMBL2047943)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MPS1 (519 to 808 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50072900(CHEMBL3410073)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-AhxPWDPDDADITEILG-NH2 as substrate preincubated for 15 mins followed by substrate addition by TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50512458(CHEMBL4450240)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of MPS1 (510 to 857 residues) catalytic domain (unknown origin) expressed in Escherichia coli after 15 mins by mass-spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50072911(CHEMBL3410084)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-AhxPWDPDDADITEILG-NH2 as substrate preincubated for 15 mins followed by substrate addition by TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50512455(CHEMBL4436510)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of MPS1 (510 to 857 residues) catalytic domain (unknown origin) expressed in Escherichia coli after 15 mins by mass-spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50420401(CHEMBL2089255 | US11208696, Example 31)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50081539(CHEMBL3422104)
Affinity DataIC50: 9nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM241235(US9409907, 77 | US10479788, Example 77 | US1104668...)
Affinity DataIC50: 11nMAssay Description:Inhibition of MPS1 (unknown origin) in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM241235(US9409907, 77 | US10479788, Example 77 | US1104668...)
Affinity DataIC50: 20nMAssay Description:Inhibition of MPS1 (unknown origin) in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50446445(CHEMBL2140523)
Affinity DataIC50: 35nMAssay Description:Inhibition of N-terminal GST-tagged full-length human Mps1 expressed in insect cells using FITC-DHTGFLTEYVATR-CONH2 as substrate after 25 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50512457(CHEMBL4474534)
Affinity DataIC50: 50nMAssay Description:Inhibition of glioblastoma patient derived MPS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 98nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 182nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50512458(CHEMBL4450240)
Affinity DataKi: <0.5nMAssay Description:Inhibition of MPS1 (510 to 857 residues) catalytic domain (unknown origin) expressed in Escherichia coli after 15 mins by mass-spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50512455(CHEMBL4436510)
Affinity DataKi: <0.5nMAssay Description:Inhibition of MPS1 (510 to 857 residues) catalytic domain (unknown origin) expressed in Escherichia coli after 15 mins by mass-spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed