Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50008147
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  10nMAssay Description:Binding affinity to TBK1 in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataKd:  251nMAssay Description:Binding affinity to TBK1 in human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataKd:  20nMAssay Description:Binding affinity to TBK1 in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  20nMAssay Description:Binding affinity to TBK1 in human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  7.94E+3nMAssay Description:Binding affinity to AAK1 in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataKd:  40nMAssay Description:Binding affinity to phosphorylated TBK1 in calyculin A stimulated human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataKd:  32nMAssay Description:Binding affinity to phosphorylated TBK1 in calyculin A stimulated human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4-kinase beta(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  5.01E+3nMAssay Description:Binding affinity to PI4KB in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by lipid-kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  158nMAssay Description:Binding affinity to phosphorylated TBK1 in calyculin A stimulated human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to IKKepsilon in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17B(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataKd:  631nMAssay Description:Binding affinity to ST17B in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataKd:  79nMAssay Description:Binding affinity to TBK1 in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataKd:  158nMAssay Description:Binding affinity to TBK1 in human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataIC50: 158nMAssay Description:Inhibition of recombinant human TBK1 using MBP as substrate in presence of gamma-33P]-ATP by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataIC50: 501nMAssay Description:Inhibition of TBK1 in human THP1 cells assessed as decrease in c-GAMP stimulated IFNbeta secretion preincubated for 45 mins followed by c-GAMP additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataIC50: 794nMAssay Description:Inhibition of TBK1 in TLR3-stimulated human PBMC assessed as decrease in poly(I:C)-induced IFNalpha secretion preincubated for 1 hr followed by poly(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TBK1 in human Ramos cells assessed as decrease in poly(I:C)-stimulated IRF3 phosphorylation at Ser396 residue preincubated for 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50516171(CHEMBL4446892)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of TBK1 in human THP1 cells assessed as decrease in baculovirus-stimulated IFNbeta secretion preincubated for 45 mins followed by virus ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed