Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50007820
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of recombinant human PDE4D2 using [3H]cAMP as substrate measured after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
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PubMed
TargetTyrosine-protein kinase ABL1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of recombinant human ABL using Ulight-TK peptide as substrate measured after 30 mins by LANCE assayMore data for this Ligand-Target Pair
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PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
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PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
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PubMed
TargetCytochrome P450 2C8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
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PubMed
TargetSubstance-K receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 2.10E+4nMAssay Description:Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
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PubMed
TargetCytochrome P450 2C19(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of human ERG by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
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PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 8.20E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM144227(US8952008, 4)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed