Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50009222
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50112342(CHEMBL3609312)
Affinity DataKd:  73nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to PLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataKd:  11nMAssay Description:Binding affinity to human PLK1 (33 to 325 residues) expressed in mammalian expression system by kinome scan-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526294(CHEMBL4588843)
Affinity DataKd:  78nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  37nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataKd:  44nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to PLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataKd:  160nMAssay Description:Binding affinity to human PLK3 (42 to 334 residues) expressed in mammalian expression system by kinome scan-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataKd:  190nMAssay Description:Binding affinity to human INSR (997 to 1318 residues) expressed in mammalian expression system by kinome scan-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataKd:  89nMAssay Description:Binding affinity to wild type human ALK (1088 to 1409 residues) expressed in mammalian expression system by kinome scan-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526309(CHEMBL4543331)
Affinity DataKd:  63nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526297(CHEMBL4448214)
Affinity DataKd:  130nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526304(CHEMBL4451065)
Affinity DataKd:  120nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526303(CHEMBL4457809)
Affinity DataKd:  69nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526302(CHEMBL4464826)
Affinity DataKd:  81nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526301(CHEMBL4456099)
Affinity DataKd:  80nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526295(CHEMBL4469087)
Affinity DataKd:  54nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526300(CHEMBL4469756)
Affinity DataKd:  73nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataKd:  23nMAssay Description:Binding affinity to human ALK F1174L mutant (1088 to 1409 residues) expressed in mammalian expression system by kinome scan-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PLK1 (unknown origin) using Ser/Thr 16 as substrate after 60 mins by Z-LYTE activity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526301(CHEMBL4456099)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of PLK1 (unknown origin) using Ser/Thr 16 as substrate after 60 mins by Z-LYTE activity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526302(CHEMBL4464826)
Affinity DataIC50: 12nMAssay Description:Inhibition of PLK1 (unknown origin) using Ser/Thr 16 as substrate after 60 mins by Z-LYTE activity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataIC50: 17nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526309(CHEMBL4543331)
Affinity DataIC50: 63nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526309(CHEMBL4543331)
Affinity DataIC50: 68nMAssay Description:Inhibition of PLK1 (unknown origin) using Ser/Thr 16 as substrate after 60 mins by Z-LYTE activity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)
Affinity DataIC50: 79nMAssay Description:Inhibition of ALK F1174L mutant auto-phosphorylation in human Kelly cells after 3 hrs by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526303(CHEMBL4457809)
Affinity DataIC50: 84nMAssay Description:Inhibition of PLK1 (unknown origin) using Ser/Thr 16 as substrate after 60 mins by Z-LYTE activity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526295(CHEMBL4469087)
Affinity DataIC50: 85nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526300(CHEMBL4469756)
Affinity DataIC50: 110nMAssay Description:Inhibition of PLK1 (unknown origin) using Ser/Thr 16 as substrate after 60 mins by Z-LYTE activity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataIC50: 125nMAssay Description:Inhibition of PLK1 (unknown origin) using Ser/Thr 16 as substrate after 60 mins by Z-LYTE activity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526305(CHEMBL4557730)
Affinity DataIC50: 150nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 180nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526297(CHEMBL4448214)
Affinity DataIC50: 210nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526307(CHEMBL4519103)
Affinity DataIC50: 220nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataIC50: 260nMAssay Description:Inhibition of full-length C-terminal NanoLuc-tagged BRD4 BD1 (unknown origin) expressed in human HEK293 cells after 2 hrs by NanoBRET target engageme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526295(CHEMBL4469087)
Affinity DataIC50: 290nMAssay Description:Inhibition of PLK1 (unknown origin) using Ser/Thr 16 as substrate after 60 mins by Z-LYTE activity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526301(CHEMBL4456099)
Affinity DataIC50: 290nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526304(CHEMBL4451065)
Affinity DataIC50: 290nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 300nMAssay Description:Inhibition of full-length C-terminal NanoLuc-tagged BRD4 BD1 (unknown origin) expressed in human HEK293 cells after 2 hrs by NanoBRET target engageme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526309(CHEMBL4543331)
Affinity DataIC50: 310nMAssay Description:Inhibition of full-length C-terminal NanoLuc-tagged BRD4 BD1 (unknown origin) expressed in human HEK293 cells after 2 hrs by NanoBRET target engageme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526299(CHEMBL4454885)
Affinity DataIC50: 350nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526294(CHEMBL4588843)
Affinity DataIC50: 370nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526308(CHEMBL4549308)
Affinity DataIC50: 370nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526302(CHEMBL4464826)
Affinity DataIC50: 380nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 390nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526303(CHEMBL4457809)
Affinity DataIC50: 440nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526296(CHEMBL4449858)
Affinity DataIC50: 470nMAssay Description:Inhibition of full-length C-terminal NanoLuc-tagged ALK (unknown origin) expressed in human HEK293 cells after 2 hrs by NanoBRET target engagement as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526300(CHEMBL4469756)
Affinity DataIC50: 490nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526298(CHEMBL4436006)
Affinity DataIC50: 520nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526295(CHEMBL4469087)
Affinity DataIC50: 540nMAssay Description:Inhibition of full-length C-terminal NanoLuc-tagged BRD4 BD1 (unknown origin) expressed in human HEK293 cells after 2 hrs by NanoBRET target engageme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
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