Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50006957
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50: 190nMAssay Description:Inhibition of human ERG expressed in CHO cells in at -80 mV holding potential by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505041(CHEMBL4533341)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505045(CHEMBL4470699)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505046(CHEMBL4559406)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505044(CHEMBL4447387)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505041(CHEMBL4533341)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition and measured for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505043(CHEMBL4460834)
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505042(CHEMBL4440308)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505047(CHEMBL4450768)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM139372(US8889671, 1)
Affinity DataIC50: 2.43E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505041(CHEMBL4533341)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 10 mins followed by NADPH addition and measured for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505041(CHEMBL4533341)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition and measured for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505041(CHEMBL4533341)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate preincubated for 10 mins followed by NADPH addition and measured for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505041(CHEMBL4533341)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505041(CHEMBL4533341)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition and measured f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505048(CHEMBL4435962)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells in at -80 mV holding potential by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505041(CHEMBL4533341)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells in at -80 mV holding potential by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505044(CHEMBL4447387)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells in at -80 mV holding potential by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505043(CHEMBL4460834)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells in at -80 mV holding potential by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505046(CHEMBL4559406)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells in at -80 mV holding potential by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 1.21E+5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505045(CHEMBL4470699)
Affinity DataIC50: 1.28E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 1.54E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505043(CHEMBL4460834)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM139372(US8889671, 1)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505041(CHEMBL4533341)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505047(CHEMBL4450768)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505046(CHEMBL4559406)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505044(CHEMBL4447387)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50505042(CHEMBL4440308)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha using catenated DNA as substrate after 30 mins by ethidium bromide-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed