Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 50007270
TargetSerine/threonine-protein kinase pim-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 0.00900nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM319575(5-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50192880(CHEMBL3984425 | US9775844, Compound 4 | US10329299...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase pim-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50387298(CHEMBL2048872)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507817(CHEMBL4476770)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of TYK2 in human Jurkat cells assessed as reduction in IFN-alpha stimulated TYK2 phosphorylation by caspase3/7 reagent-based Western blot ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 1nMAssay Description:Inhibition of MNK2 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50040805(CHEMBL3361255)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28031(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of RON (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50387298(CHEMBL2048872)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataIC50: 2nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 2nMAssay Description:Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50387298(CHEMBL2048872)
Affinity DataIC50: 5nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM184556(US9150579, B1)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50427138(CHEMBL2323775 | MK-8033)
Affinity DataIC50: 7nMAssay Description:Inhibition of RON (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 7nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50040806(CHEMBL3361254)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50324735(CHEMBL568150 | AS605240 | (5E)-5-(QUINOXALIN-6-YLM...)
Affinity DataIC50: 8nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50252542(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Affinity DataIC50: 13nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50015639(CHEMBL3260567 | USRE47141, Example 2)
Affinity DataIC50: 13nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507818(CHEMBL4450504)
Affinity DataIC50: 15nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50192880(CHEMBL3984425 | US9775844, Compound 4 | US10329299...)
Affinity DataIC50: 17nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507817(CHEMBL4476770)
Affinity DataIC50: 23nMAssay Description:Inhibition of JAK1 in human Jurkat cells assessed as reduction in IFN-alpha stimulated JAK1 phosphorylation by caspase3/7 reagent-based Western blot ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50192880(CHEMBL3984425 | US9775844, Compound 4 | US10329299...)
Affinity DataIC50: 23nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507817(CHEMBL4476770)
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK2 in human Jurkat cells assessed as reduction in IFN-alpha stimulated JAK2 phosphorylation by caspase3/7 reagent-based Western blot ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 27nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50004547(CHEMBL2216863 | US9708333, 28 | US10065963, Compou...)
Affinity DataIC50: 31nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM390174(US9951086, Example 64)
Affinity DataIC50: 33nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50204834(2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pterid...)
Affinity DataIC50: 35nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507817(CHEMBL4476770)
Affinity DataIC50: 41nMAssay Description:Inhibition of JAK3 in human Jurkat cells assessed as reduction in IFN-alpha stimulated JAK3 phosphorylation by caspase3/7 reagent-based Western blot ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50246769(CHEMBL4064608)
Affinity DataIC50: 51nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50015640(LY-2157299 | GALUNISERTIB)
Affinity DataIC50: 56nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50324735(CHEMBL568150 | AS605240 | (5E)-5-(QUINOXALIN-6-YLM...)
Affinity DataIC50: 60nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataIC50: 63nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 64nMAssay Description:Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 69nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50110208(SB-431542 | cid_4521392 | 4-(5-(benzo[d][1,3]dioxo...)
Affinity DataIC50: 70nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50192880(CHEMBL3984425 | US9775844, Compound 4 | US10329299...)
Affinity DataIC50: 82nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM25084(JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...)
Affinity DataIC50: 83nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 85nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 86nMAssay Description:Inhibition of MNK2 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM25084(JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...)
Affinity DataIC50: 235nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50324735(CHEMBL568150 | AS605240 | (5E)-5-(QUINOXALIN-6-YLM...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952329 | CHEMBL1952141)
Affinity DataIC50: 363nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataIC50: 800nMAssay Description:Inhibition of human N-terminal His-tagged PI3Kalpha/p85alpha expressed in Spodoptera frugiperda using phosphatidylinositol as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 870nMAssay Description:Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507818(CHEMBL4450504)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of human full length recombinant N-terminal His-tagged PI3Kbeta/p85alpha expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM25084(JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
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