Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50018720
TargetSubstance-P receptor(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067933(5-[(2S,3S)-2-(3,5-Bis-trifluoromethyl-benzyloxy)-3...)
Affinity DataIC50: 0.0700nMAssay Description:Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSubstance-P receptor(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50220136(CHEMBL1471 | 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluo...)
Affinity DataIC50: 0.0900nMAssay Description:Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50139181(2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of rat liver HMG-CoA reductase pre incubated for 5 mins followed by substrate addition using NADPH as substrate by scintillation counter a...More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM34168(cid_53232 | SMR000058779 | MLS000069585 | LOVASTAT...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of rat liver HMG-CoA reductase pre incubated for 5 mins followed by substrate addition using NADPH as substrate by scintillation counter a...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBreakpoint cluster region protein(Mouse)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 38nMAssay Description:Inhibition of Bcr-Abl phosphorylation in BALB/c mouse 3T3 by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor beta(Mouse)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 50nMAssay Description:Inhibition of PDGFR phosphorylation in BALB/c mouse 3T3 by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBreakpoint cluster region protein(Mouse)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50290422(4-(4-Methyl-piperazin-1-ylmethyl)-N-[3-(4-pyridin-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Bcr-Abl phosphorylation in BALB/c mouse 3T3 by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor beta(Mouse)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50290422(4-(4-Methyl-piperazin-1-ylmethyl)-N-[3-(4-pyridin-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PDGFR phosphorylation in BALB/c mouse 3T3 by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50290422(4-(4-Methyl-piperazin-1-ylmethyl)-N-[3-(4-pyridin-...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of c-Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetcAMP-dependent protein kinase catalytic subunit gamma(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50290422(4-(4-Methyl-piperazin-1-ylmethyl)-N-[3-(4-pyridin-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50290422(4-(4-Methyl-piperazin-1-ylmethyl)-N-[3-(4-pyridin-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PKC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of c-Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetOrexin receptor type 2(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM104689(US8569311, A-9)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human OX2R by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetOrexin receptor type 2(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM104692(US8569311, E-5)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity at human OX2R by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMu-type opioid receptor(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50088381(ADL 8-2698 | Alvimopan | Entereg)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]DAMGO from human cloned mu-opioid receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetOrexin/Hypocretin receptor type 1(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM104689(US8569311, A-9)
Affinity DataKi:  1nMAssay Description:Antagonist activity at human OX1R by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM104692(US8569311, E-5)
Affinity DataKi:  2.5nMAssay Description:Antagonist activity at human OX1R by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetOrexin receptor type 2(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092810(CHEMBL3586412)
Affinity DataKi:  5nMAssay Description:Antagonist activity at human OX2R by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetOrexin receptor type 2(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50611825(CHEMBL5273790)
Affinity DataKi:  29nMAssay Description:Antagonist activity at human OX2R by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMu-type opioid receptor(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50045772(3-((3R,4R)-1,3,4-Trimethyl-piperidin-4-yl)-phenol ...)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]DAMGO from human cloned mu-opioid receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50611825(CHEMBL5273790)
Affinity DataKi:  96nMAssay Description:Antagonist activity at human OX1R by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50611824(CHEMBL118755)
Affinity DataKi:  115nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092810(CHEMBL3586412)
Affinity DataKi:  150nMAssay Description:Antagonist activity at human OX1R by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50611823(CHEMBL1184118)
Affinity DataKi:  248nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed