Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50003099
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential of -120 mV by manual electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Nav1.7 (unknown origin) by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466967(CHEMBL4282994)
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to recombinant human Nav1.7 after 18 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466965(CHEMBL4294255)
Affinity DataIC50: 13nMAssay Description:Binding affinity to recombinant human Nav1.7 after 18 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466968(CHEMBL4289786)
Affinity DataIC50: 15nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466963(CHEMBL4208190)
Affinity DataIC50: 19nMAssay Description:Inhibition of Nav1.7 (unknown origin) by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466964(Pf-05241328)
Affinity DataIC50: 31nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466969(CHEMBL4287442 | US10668067, Example 1-4)
Affinity DataIC50: 33nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 3 mins by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466966(CHEMBL4290861)
Affinity DataIC50: 38nMAssay Description:Binding affinity to recombinant human Nav1.7 after 18 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 702nMAssay Description:Inhibition of human Nav1.7 expressed in CHO cells at holding potential of -100 mV by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50466962(CHEMBL4286792)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.7 expressed in CHO cells at holding potential of -100 mV by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed