Compile Data Set for Download or QSAR
Report error Found 99 Enz. Inhib. hit(s) with all data for entry = 50002359
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50014945(alpha-methyl-5-HT | alpha-methyl-5-hydroxytryptami...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  98nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50001955(APOKYN | CHEMBL53 | (Apomorphine) 6-Methyl-5,6,6a,...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human D2 receptor expressed in CHO-K1 cells co-expressing Galphaqi5 assessed as increase in calcium mobilization measured for 30 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457576(CHEMBL4212812)
Affinity DataEC50:  757nMAssay Description:Agonist activity at human D2 receptor expressed in CHO-K1 cells co-expressing Galphaqi5 assessed as increase in calcium mobilization measured for 30 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataIC50: 0.930nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO-K1 cells co-expressing Galphaqi5 assessed as decrease in apomorphine-induced calcium mobili...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM82517(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Affinity DataIC50: 4.70nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457578(CHEMBL4209888)
Affinity DataIC50: 7.20nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM139370(ACP-103 | Pimavanserin | Pimavanserin hydrochlorid...)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50047471(N-tert-Butyl-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457578(CHEMBL4209888)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO-K1 cells co-expressing Galphaqi5 assessed as decrease in apomorphine-induced calcium mobili...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457572(CHEMBL4207653)
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457577(CHEMBL4213352)
Affinity DataIC50: 79nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO-K1 cells co-expressing Galphaqi5 assessed as decrease in apomorphine-induced calcium mobili...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457572(CHEMBL4207653)
Affinity DataIC50: 82nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO-K1 cells co-expressing Galphaqi5 assessed as decrease in apomorphine-induced calcium mobili...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457576(CHEMBL4212812)
Affinity DataIC50: 291nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457577(CHEMBL4213352)
Affinity DataIC50: 376nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457573(CHEMBL4205526)
Affinity DataIC50: 595nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457578(CHEMBL4209888)
Affinity DataIC50: 1.05E+3nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457581(CHEMBL4203310)
Affinity DataIC50: 1.18E+3nMAssay Description:Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457572(CHEMBL4207653)
Affinity DataIC50: 1.84E+3nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457577(CHEMBL4213352)
Affinity DataIC50: 2.34E+3nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457577(CHEMBL4213352)
Affinity DataIC50: 4.01E+3nMAssay Description:Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457576(CHEMBL4212812)
Affinity DataIC50: 5.79E+3nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457579(CHEMBL4217761)
Affinity DataIC50: 6.97E+3nMAssay Description:Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457572(CHEMBL4207653)
Affinity DataIC50: 1.82E+4nMAssay Description:Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457576(CHEMBL4212812)
Affinity DataIC50: 8.58E+4nMAssay Description:Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457575(CHEMBL3979261)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]8-OH-DPAT from Wistar rat 5-HT1A receptor after 20 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]LSD from recombinant human 5-HT6 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM152784(CHEMBL4218586 | 1-[(2,4,6-trimethylphenoxy)propyl]...)
Affinity DataKi: <1nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cell membranes after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22875(Vistaril | CHEMBL896 | 2-(2-{4-[(4-chlorophenyl)(p...)
Affinity DataKi:  2nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457578(CHEMBL4209888)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457575(CHEMBL3979261)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]prazosin from rat cerebral cortex adrenergic receptor alpha1 by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50222218(CHEBI:51137 | Mianserin)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457572(CHEMBL4207653)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]methylspiperonee from recombinant human D2 receptor expressed in HEK293 cells cell membranes after 60 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457578(CHEMBL4209888)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha1 adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha1 adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457577(CHEMBL4213352)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha1 adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457578(CHEMBL4209888)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457572(CHEMBL4207653)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha1 adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457576(CHEMBL4212812)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM152785(1-[(2,6-dimethylphenoxy)ethoxyethyl]-4-(2-methoxyp...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-prazosin from Wistar rat cerebral cortex membranes alpha1 adrenoceptor by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457575(CHEMBL3979261)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457577(CHEMBL4213352)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457579(CHEMBL4217761)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]prazosin from recombinant human alpha1 adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22875(Vistaril | CHEMBL896 | 2-(2-{4-[(4-chlorophenyl)(p...)
Affinity DataKi:  50nMAssay Description:Binding affinity to 5-HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50457572(CHEMBL4207653)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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