Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50002070
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453060(CHEMBL4203893)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453029(CHEMBL4216115)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453052(CHEMBL4203378)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453028(CHEMBL4204225)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453045(CHEMBL4215570)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453065(CHEMBL4212402)
Affinity DataIC50: 23nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453029(CHEMBL4216115)
Affinity DataIC50: 27nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: 38nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453030(CHEMBL4208166)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)
Affinity DataIC50: 48nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453052(CHEMBL4203378)
Affinity DataIC50: 50nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453060(CHEMBL4203893)
Affinity DataIC50: 53nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453031(CHEMBL4211143)
Affinity DataIC50: 66nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453064(CHEMBL4206773)
Affinity DataIC50: 76nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453028(CHEMBL4204225)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453045(CHEMBL4215570)
Affinity DataIC50: 140nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: 160nMAssay Description:Inhibition of caspase-1 in human monocyte-derived macrophages assessed as decrease in LPS-induced IL-1beta secretion after 24 hrs by sandwich immunoa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453061(CHEMBL4203155)
Affinity DataIC50: 200nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453062(CHEMBL4207501)
Affinity DataIC50: 210nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453063(CHEMBL4216830)
Affinity DataIC50: 360nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453040(CHEMBL4218951)
Affinity DataIC50: 501nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453027(CHEMBL4208767)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-5(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of human recombinant caspase-5 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453054(CHEMBL4213265)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453040(CHEMBL4218951)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-3(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-3 using Ac-DEVD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-6(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-6 using Ac-VEID-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-8(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-8 using Ac-IETD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-7(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-7 using Ac-DEVD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453044(CHEMBL4214469)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453035(CHEMBL4215229)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453043(CHEMBL4202809)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453059(CHEMBL4213490)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453054(CHEMBL4213265)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453035(CHEMBL4215229)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453042(CHEMBL4215468)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453059(CHEMBL4213490)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453042(CHEMBL4215468)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453041(CHEMBL4209211)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453041(CHEMBL4209211)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453044(CHEMBL4214469)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453043(CHEMBL4202809)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453027(CHEMBL4208767)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed