Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50001688
LigandPNGBDBM50303802(CHEMBL4169380)
Affinity DataKd:  150nMAssay Description:Binding affinity to MCL1 (unknown origin) by surface plasma resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM203869(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM203875(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM203870(7-(3-((3-Acetyl-4-boronophenoxy)methyl)-1,5-dimeth...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM203876(Mcl-1 inhibitor 12)
Affinity DataIC50: 6nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM203871(7-(3-((3-formylphenoxy)methyl)-1,5-dimethyl-1H-pyr...)
Affinity DataIC50: 60nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50303987(CHEMBL4163417)
Affinity DataIC50: 162nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM203872(7-(3-((3-Acetylphenoxy)methyl)-1,5-dimethyl-1H-pyr...)
Affinity DataIC50: 237nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM203874(Mcl-1 inhibitor 10)
Affinity DataIC50: 383nMAssay Description:Inhibition of FAM labelled Bid-BH3 binding to N-terminal GST-tagged human recombinant MCL1 expressed in Escherichia coli BL2(DE3) after 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50376902(CHEMBL408194)
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50376902(CHEMBL408194)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50376902(CHEMBL408194)
Affinity DataIC50: 4.69E+3nMAssay Description:Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50013890(CHEMBL3265288)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of recombinant FITC tagged MCL1 SAHBA binding to MCL1 deltaNdeltaC (unknown origin) expressed in Escherichia coli BL21 (DE3) by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50303762(CHEMBL3393633)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of biotin labelled Bid-BH3 binding to GST-tagged MCL1 (unknown origin) preincubated for 15 mins followed by biotin labelled Bid-BH3 additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50266967(CHEMBL3393621 | CHEBI:66678)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of biotin labelled Bid-BH3 binding to N-terminal truncated 151/C-terminal truncated of 23 residues GST-tagged mouse MCL1 expressed in Esch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50266967(CHEMBL3393621 | CHEBI:66678)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of biotin labelled Bid-BH3 binding to C-terminal GST-tagged human BCL-XL transmembrane domain expressed in Escherichia coli BL21 (DE3) pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50303762(CHEMBL3393633)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of biotin labelled Bid-BH3 binding to GST-tagged BCL-XL (unknown origin) preincubated for 15 mins followed by biotin labelled Bid-BH3 addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of Bcl-2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50304179(CHEMBL4159388)
Affinity DataKi: <1nMAssay Description:Inhibition of His6 tagged MBP fused Mcl-1 (unknown origin) after 0.5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50270877(ABT-263 | (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimeth...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50270877(ABT-263 | (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimeth...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBcl-2-like protein 1(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  48nMAssay Description:Inhibition of Bcl-xL (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50303503(CHEMBL4160782 | US10858316, Compound SF-5-141)
Affinity DataKi:  120nMAssay Description:Inhibition of FITC-BAK binding to His6 tagged MBP fused recombinant human MCL1 (172 to 327 residues) expressed in Escherichia coli by fluorescence po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50303216(CHEMBL4165406)
Affinity DataKi:  180nMAssay Description:Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50303352(CHEMBL4164057)
Affinity DataKi:  180nMAssay Description:Inhibition of N-terminal 26 residues truncated 5-FAM labelled Bid-BH3 binding to MCL1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50303139(CHEMBL4171930)
Affinity DataKi:  320nMAssay Description:Inhibition of N-terminal 26 residues truncated 5-FAM labelled Bid-BH3 binding to MCL1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50303216(CHEMBL4165406)
Affinity DataKi:  320nMAssay Description:Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi: >444nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50303216(CHEMBL4165406)
Affinity DataKi:  480nMAssay Description:Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50304178(CHEMBL4164713)
Affinity DataKi:  480nMAssay Description:Displacement of FAM labelled Bid-derived peptide from MCL1 (unknown origin) incubated for 1 min by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM53290(2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynapht...)
Affinity DataKi:  490nMAssay Description:Inhibition of MCL1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50270877(ABT-263 | (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimeth...)
Affinity DataKi:  550nMAssay Description:Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKi:  1.55E+3nMAssay Description:Inhibition of MCL1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
LigandPNGBDBM50303215(CHEMBL4167501)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of FITC-BAK binding to MCL1 (172 to 327 residues) (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50304178(CHEMBL4164713)
Affinity DataKi:  3.60E+3nMAssay Description:Displacement of FAM labelled Bid-derived peptide from Bcl-2 (unknown origin) incubated for 1 min by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed