Compile Data Set for Download or QSAR
Report error Found 136 Enz. Inhib. hit(s) with all data for entry = 50008312
TargetKappa-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50001465(2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl...)
Affinity DataEC50:  80nMAssay Description:Activation of kappa opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50517884(CHEMBL439458)
Affinity DataEC50:  4.40nMAssay Description:Partial agonist activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50517885(CHEMBL424859)
Affinity DataEC50:  5.5nMAssay Description:Partial agonist activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50517886(CHEMBL428635)
Affinity DataEC50:  9.10nMAssay Description:Partial agonist activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50517886(CHEMBL428635)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to human PTH receptor expressed in OK-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of kappa opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  60nMAssay Description:Activation of mu opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM87047(Bisanilinopyrimidine, 3h | Bisanilinopyrimidine in...)
Affinity DataKd:  39nMAssay Description:Binding affinity to His6 tagged MBP fused human aurora A (123 to 390 residues) expressed in Escherichia coli Tuner (DE3) cells by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50517885(CHEMBL424859)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to human PTH receptor expressed in OK-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50142317((2-bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl)difluo...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of PTP1B (unknown origin) expressed in sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50517884(CHEMBL439458)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to human PTH receptor expressed in OK-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  5nMAssay Description:Activation of delta opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50517918(CHEMBL276472)
Affinity DataEC50:  7.90nMAssay Description:Partial agonist activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50517918(CHEMBL276472)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to human PTH receptor expressed in OK-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM87052(Bisanilinopyrimidine, 6a | Bisanilinopyrimidine in...)
Affinity DataKd:  16nMAssay Description:Binding affinity to His6 tagged MBP fused human aurora A (123 to 390 residues) expressed in Escherichia coli Tuner (DE3) cells by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50340481(Avodart | GG-745 | GI-198745 | CHEMBL1200969 | DUT...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human type 2 5alpha reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human type 2 5alpha reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50: 0.200nMAssay Description:Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1D(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50065419(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50152012(5-{4-[4-(5-Fluoro-1H-indol-3-yl)-butyl]-piperazin-...)
Affinity DataIC50: 0.300nMAssay Description:inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50151988(3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pipera...)
Affinity DataIC50: 0.400nMAssay Description:inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50: 0.5nMAssay Description:inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50152022(3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-buty...)
Affinity DataIC50: 0.600nMAssay Description:inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50152022(3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-buty...)
Affinity DataIC50: 0.700nMAssay Description:Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517890(CHEMBL4434792)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of His6 tagged MBP fused human aurora A (123 to 390 residues) expressed in Escherichia coli Tuner (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50065417(3-[3-(4-Benzyl-4-fluoro-piperidin-1-yl)-propyl]-5-...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50400849(CHEMBL2203634)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50151988(3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pipera...)
Affinity DataIC50: 1nMAssay Description:Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50152002(3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-buty...)
Affinity DataIC50: 1nMAssay Description:inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50152015(3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pipera...)
Affinity DataIC50: 1nMAssay Description:inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human type 2 5alpha reductase expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517880(CHEMBL4569322)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human type 2 5alpha reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50400847(CHEMBL2203635)
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50044311(Trifluoro-methanesulfonamide | TRIFLUOROMETHANE SU...)
Affinity DataIC50: 2nMAssay Description:Inhibition of bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50152012(5-{4-[4-(5-Fluoro-1H-indol-3-yl)-butyl]-piperazin-...)
Affinity DataIC50: 3nMAssay Description:Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517901(CHEMBL4540042)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human type 2 5alpha reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM87052(Bisanilinopyrimidine, 6a | Bisanilinopyrimidine in...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of His6 tagged MBP fused human aurora A (123 to 390 residues) expressed in Escherichia coli Tuner (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517880(CHEMBL4569322)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human type 1 5alpha reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50340481(Avodart | GG-745 | GI-198745 | CHEMBL1200969 | DUT...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human type 1 5alpha reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50152002(3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-buty...)
Affinity DataIC50: 4nMAssay Description:Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50152015(3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pipera...)
Affinity DataIC50: 5nMAssay Description:Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50338038(US8575391, 334 | 3,4-difluoro-2-[(2-fluoro-4-iodop...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of MAPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50151997(3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pipera...)
Affinity DataIC50: 8nMAssay Description:Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517899(CHEMBL4447539)
Affinity DataIC50: 9nMAssay Description:Inhibition of human androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM87047(Bisanilinopyrimidine, 3h | Bisanilinopyrimidine in...)
Affinity DataIC50: 10nMAssay Description:Inhibition of His6 tagged MBP fused human aurora A (123 to 390 residues) expressed in Escherichia coli Tuner (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50400855(CHEMBL2203638)
Affinity DataIC50: 10nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50151997(3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pipera...)
Affinity DataIC50: 10nMAssay Description:inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 5HT1B expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50065417(3-[3-(4-Benzyl-4-fluoro-piperidin-1-yl)-propyl]-5-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human 5HT1B expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
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