Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50002155
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454186(CHEMBL4215914)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK2 (M1 to L298 residues)/CyclinE1 (M1 to A395 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454183(CHEMBL4204229)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK2 (M1 to L298 residues)/CyclinE1 (M1 to A395 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454185(CHEMBL4215776)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK2 (M1 to L298 residues)/CyclinE1 (M1 to A395 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50025724(N-(2-Dimethylamino-ethyl)-4-(1,3-dimethyl-7-oxo-6,...)
Affinity DataIC50: 68nMAssay Description:Displacement of N6-[3H]Cyclohexyladenosine from adenosine A1 receptor in rat brain membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50025699(5-(2-Amino-phenyl)-1,3-dimethyl-1,6-dihydro-pyrazo...)
Affinity DataIC50: 230nMAssay Description:Displacement of N6-[3H]Cyclohexyladenosine from adenosine A1 receptor in rat brain membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50025701(1-Ethyl-3-methyl-5-pyridin-4-yl-1,6-dihydro-pyrazo...)
Affinity DataIC50: 250nMAssay Description:Displacement of N6-[3H]Cyclohexyladenosine from adenosine A1 receptor in rat brain membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454182(CHEMBL4210771)
Affinity DataIC50: 440nMAssay Description:Inhibition of recombinant human full length N-terminal GST/His6-tagged CDK5 (M1 to P292 residues)/N-terminal His6-tagged p25NCK (A104 to R307 residue...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50132175(2-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Affinity DataIC50: 440nMAssay Description:Inhibition of CDK1/CyclinB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454182(CHEMBL4210771)
Affinity DataIC50: 990nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK2 (M1 to M298 residues)/CyclinA2 (M1 to V432 residues) expressed in Sf9 insect c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454182(CHEMBL4210771)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human full length N-terminal GST/His6-tagged CDK9 (M1 to F372 residues)/N-terminal His6-tagged CyclinT1 (M1 to K726 residue...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454184(CHEMBL4205015)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK2 (M1 to M298 residues)/CyclinA2 (M1 to V432 residues) expressed in Sf9 insect c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454184(CHEMBL4205015)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant human full length N-terminal GST/His6-tagged CDK5 (M1 to P292 residues)/N-terminal His6-tagged p25NCK (A104 to R307 residue...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454184(CHEMBL4205015)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human full length N-terminal GST/His6-tagged CDK9 (M1 to F372 residues)/N-terminal His6-tagged CyclinT1 (M1 to K726 residue...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454182(CHEMBL4210771)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged CDK1 (M1 to M297 residues)/CyclinB1 (M1 to V433 residues) expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454184(CHEMBL4205015)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged CDK1 (M1 to M297 residues)/CyclinB1 (M1 to V433 residues) expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454184(CHEMBL4205015)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK4 (S4 to E303 residues)/CyclinD1 (Q4 to I295 residues) expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK1/CyclinB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454182(CHEMBL4210771)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK4 (S4 to E303 residues)/CyclinD1 (Q4 to I295 residues) expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454184(CHEMBL4205015)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK6 (M1 to A326 residues)/CyclinD1 (Q4 to I295 residues) expressed in Sf9 insect c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50454184(CHEMBL4205015)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human full length N-terminal GST/His6-tagged CDK7 (M1 to F346 residues)/N-terminal His6-tagged CyclinH (M1 to L323 residues...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50454182(CHEMBL4210771)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human full length N-terminal GST/His6-tagged CDK7 (M1 to F346 residues)/N-terminal His6-tagged CyclinH (M1 to L323 residues...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50454182(CHEMBL4210771)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK6 (M1 to A326 residues)/CyclinD1 (Q4 to I295 residues) expressed in Sf9 insect c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50116123(Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-2H-pyr...)
Affinity DataKi:  2nMAssay Description:Displacement of 125I-sauvagine from CRF1 receptor in human IMR-32 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50116095([3-(2,4-Dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[...)
Affinity DataKi:  2nMAssay Description:Displacement of 125I-sauvagine from CRF1 receptor in human IMR-32 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50116093([3-(2,4-Dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[...)
Affinity DataKi:  3nMAssay Description:Displacement of 125I-sauvagine from CRF1 receptor in human IMR-32 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50116118([3-(2,4-Dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[...)
Affinity DataKi:  3nMAssay Description:Displacement of 125I-sauvagine from CRF1 receptor in human IMR-32 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed