Compile Data Set for Download or QSAR
Report error Found 178 Enz. Inhib. hit(s) with all data for entry = 50001971
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR exon 19 deletion mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 33nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451288(CHEMBL4212450)
Affinity DataIC50: 100nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...)
Affinity DataIC50: 110nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451288(CHEMBL4212450)
Affinity DataIC50: 200nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451307(CHEMBL4203110)
Affinity DataIC50: 230nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451309(CHEMBL4215496)
Affinity DataIC50: 260nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451309(CHEMBL4215496)
Affinity DataIC50: 390nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 494nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451307(CHEMBL4203110)
Affinity DataIC50: 520nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451291(CHEMBL4208712)
Affinity DataIC50: 650nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 730nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451285(CHEMBL4214040)
Affinity DataIC50: 860nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451298(CHEMBL4211573)
Affinity DataIC50: 940nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451291(CHEMBL4208712)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451285(CHEMBL4214040)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451292(CHEMBL4202413)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451299(CHEMBL4209119)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451279(CHEMBL4207305)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451289(CHEMBL4216784)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451294(CHEMBL4215164)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451279(CHEMBL4207305)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451307(CHEMBL4203110)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451309(CHEMBL4215496)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451294(CHEMBL4215164)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451293(CHEMBL4204937)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451299(CHEMBL4209119)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451307(CHEMBL4203110)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451279(CHEMBL4207305)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451299(CHEMBL4209119)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451279(CHEMBL4207305)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451294(CHEMBL4215164)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451299(CHEMBL4209119)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451289(CHEMBL4216784)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451287(CHEMBL4204596)
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451300(CHEMBL4210744)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451300(CHEMBL4210744)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451310(CHEMBL4218320)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451288(CHEMBL4212450)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of EGFR in human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451288(CHEMBL4212450)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451294(CHEMBL4215164)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451293(CHEMBL4204937)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451296(CHEMBL4203804)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451298(CHEMBL4211573)
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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