Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50000686
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 24nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258266(CHEMBL4088107)
Affinity DataIC50: 53nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258301(CHEMBL4104510)
Affinity DataIC50: 490nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258303(CHEMBL4064136)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258307(CHEMBL4085701)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258306(CHEMBL4094364)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258305(CHEMBL4102110)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258297(CHEMBL4076518)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE3A (669 to 1141 residues) expressed in baculovirus infected Sf9 cells using [3H]cAMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258265(CHEMBL4068494)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258302(CHEMBL4086618)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of recombinant human PDE10A2 expressed in African green monkey COS7 cells using [3H]cGMP as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE11A4 expressed in baculovirus infected Sf9 cell expression system using [3H]cGMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE9A2 expressed in baculovirus infected Sf9 cell expression system using [3H]cGMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE8A1 expressed in baculovirus infected Sf9 cell expression system using [3H]cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDE6A/PDE6B expressed in baculovirus infected Sf9 cell expression system using [3H]cGMP as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE5A1 expressed in baculovirus infected Sf9 cell expression system using [3H]cGMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human GST-tagged PDE1A expressed in baculovirus infected Sf9 cell expression system using [3H]cGMP as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE4D2 (2 to 507 residues) expressed in baculovirus infected Sf9 cell expression system using [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258268(CHEMBL4059831 | US11419874, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged/C-terminal His-tagged PDE7B (109 to end residues) expressed in baculovirus infected Sf9 cell ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258300(CHEMBL4066865)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258309(CHEMBL4065234)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258304(CHEMBL4077849)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258308(CHEMBL4101192)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258258(CHEMBL4083192)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258259(CHEMBL4103591)
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258296(CHEMBL4074901)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258295(CHEMBL4095339)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258310(CHEMBL4095833)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258267(CHEMBL4080230)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258260(CHEMBL4079320)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258257(CHEMBL4066287)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50258311(CHEMBL4087643)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed