Compile Data Set for Download or QSAR
Report error Found 79 Enz. Inhib. hit(s) with all data for entry = 50049007
TargetNuclear receptor subfamily 1 group I member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232803(CHEMBL4068023)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232815(CHEMBL4104743)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232797(CHEMBL4073922)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232804(CHEMBL4087716)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232813(CHEMBL4097859)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232800(CHEMBL4103166)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232796(CHEMBL4094483)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232799(CHEMBL4078886)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232803(CHEMBL4068023)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232798(CHEMBL4095413)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232809(CHEMBL4065154)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232805(CHEMBL4069979)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232802(CHEMBL4105593)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232791(CHEMBL4062863)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232795(CHEMBL4092276)
Affinity DataIC50: 8nMAssay Description:Inhibition of NK3 receptor (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232803(CHEMBL4068023)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232811(CHEMBL4105323)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232794(CHEMBL4082016)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232793(CHEMBL4100026)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50192821(CHEMBL2133556)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by W...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232816(CHEMBL4097174)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232797(CHEMBL4073922)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232804(CHEMBL4087716)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232801(CHEMBL4079837)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50192821(CHEMBL2133556)
Affinity DataIC50: 48nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by W...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232813(CHEMBL4097859)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232806(CHEMBL4072053)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232809(CHEMBL4065154)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232798(CHEMBL4095413)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232799(CHEMBL4078886)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232800(CHEMBL4103166)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232815(CHEMBL4104743)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232812(CHEMBL4100988)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50232795(CHEMBL4092276)
Affinity DataIC50: 100nMAssay Description:Inhibition of NK2 receptor (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232802(CHEMBL4105593)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232816(CHEMBL4097174)
Affinity DataIC50: 130nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50192821(CHEMBL2133556)
Affinity DataIC50: 133nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by Who...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232805(CHEMBL4069979)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232791(CHEMBL4062863)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232796(CHEMBL4094483)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232794(CHEMBL4082016)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232808(CHEMBL4071019)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232795(CHEMBL4092276)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232792(CHEMBL4074240)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232810(CHEMBL4062385)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232793(CHEMBL4100026)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232811(CHEMBL4105323)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232806(CHEMBL4072053)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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