Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50002119
TargetProtein O-GlcNAcase(Rat)
Temple University

Curated by ChEMBL
LigandPNGBDBM50323697(thiamet-G | (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(H...)
Affinity DataEC50:  30nMAssay Description:Inhibition of O-GlcNAcase in rat PC12 cells assessed as induction of OGlcNAcylation after 24 hrs by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50138764((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50067584(2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bipheny...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50453819(CHEMBL4210419)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of FTase (unknown origin) using H-ras as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50453817(CHEMBL4218727)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant FTaseMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of rat brain FTase assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLS after 30 mins by liquid scintillat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of NEDD8 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50076128((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GGTase1 isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]H]geranylgeranyl from [3H]geranylgeranyl P...More data for this Ligand-Target Pair
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PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human RIPK2 expressed in Sf9 cells after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50370385(R-11577 | R-115777 | Tipifarnib | Zarnestra | (R)-...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of FTase isolated from Kirsten virus-transformed human osteosarcoma cells using K-rasB peptide as substrate in presence of [3H]farnesyl PP...More data for this Ligand-Target Pair
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PubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Neosartorya fumigata (Aspergillus fumigatus))
Temple University

Curated by ChEMBL
LigandPNGBDBM50033418(CHEMBL3357685)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant Aspergillus fumigatus NMT (Gln86 to Leu492 residues) expressed in Escherichia coli BL21(DE3) pLysS cells using [3H]-myristo...More data for this Ligand-Target Pair
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PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50453816(BGB-283 | Bgb 283 | Lifirafenib)
Affinity DataIC50: 23nMAssay Description:Inhibition of BRAF (unknown origin) using MEK1 K97R mutant as substrate preincubated for 60 to 120 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50453818(CHEMBL4202636)
Affinity DataIC50: 41nMAssay Description:Inhibition of FTase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50076141(2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphth...)
Affinity DataIC50: 50nMAssay Description:Inhibition of GGTase1 isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]H]geranylgeranyl from [3H]geranylgeranyl P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50076141(2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50134315(CHEMBL331627 | 7-hydroxy-11-hydroxymethyl-12-methy...)
Affinity DataIC50: 510nMAssay Description:Inhibition of petit-LUBAC (unknown origin)-mediated ubiquitylation expressed in Escherichia coli BL21 after 2 hrs in presence of E1, UbcH5c, E3 and u...More data for this Ligand-Target Pair
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PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM29315(2-amino-1,3,4-thiadiazole, 9)
Affinity DataIC50: 700nMAssay Description:Inhibition of JNK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin-like modifier-activating enzyme 6(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of UBA6 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50370385(R-11577 | R-115777 | Tipifarnib | Zarnestra | (R)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GGTase1 isolated from Kirsten virus-transformed human osteosarcoma cells using biotin-YRASNRSCAIL peptide as substrate after 120 mins i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50453818(CHEMBL4202636)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GGTase1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Rat)
Temple University

Curated by ChEMBL
LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat brain GGTase1 assessed as decrease in transfer of [3H]H]geranylgeranyl from [3H]geranylgeranyl PPi to H-Ras-CVLL after 30 mins by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin-like modifier-activating enzyme ATG7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ATG7 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSUMO-activating enzyme subunit 1/2(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SAE (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase p300(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50151658(CHEMBL3775671)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of p300 catalytic domain (unknown origin) using histone H3 as substrate preincubated for 15 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50076142((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GGTase1 (unknown origin) expressed in mouse NIH-3T3 cells transfected with k-Ras4B assessed as decrease in geranylgeranylation of k-Ras...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase p300(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of full length His6-tagged recombinant p300 (unknown origin) expressed in baculovirus infected Sf21 cells using human histone as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50076142((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of FTase (unknown origin) expressed in mouse NIH-3T3 cells cells transfected with human H-Ras assessed as decrease in farnesylation of H-R...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein O-GlcNAcase(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50323697(thiamet-G | (3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(H...)
Affinity DataKi:  21nMAssay Description:Inhibition of recombinant human O-GlcNAcase using pNP-GlcNAc as substrate measured for 5 mins by UV-VIS spectrophotometerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase p300(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50453820(CHEMBL4208500)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of VMA intein chitin binding domain-fused p300 HAT domain M1652G mutant (unknown origin) expressed in Escherichia coli BL21(RI...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed