Compile Data Set for Download or QSAR
Report error Found 56 Enz. Inhib. hit(s) with all data for entry = 50000083
TargetNuclear receptor subfamily 1 group I member 2(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataEC50:  1.60E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240278(CHEMBL4062780)
Affinity DataEC50:  5.60E+3nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240279(CHEMBL4080553)
Affinity DataIC50: 5nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 8nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240280(CHEMBL4065038)
Affinity DataIC50: 10nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240294(CHEMBL4100134)
Affinity DataIC50: 12nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240278(CHEMBL4062780)
Affinity DataIC50: 12nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240278(CHEMBL4062780)
Affinity DataIC50: 13nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 15nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240282(CHEMBL4090731)
Affinity DataIC50: 27nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50024250(CHEMBL2324000)
Affinity DataIC50: 28nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at -120 mV holding potential measured for 8 sec by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240291(CHEMBL4064700)
Affinity DataIC50: 30nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240292(CHEMBL4092379)
Affinity DataIC50: 44nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240289(CHEMBL4102586)
Affinity DataIC50: 45nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240290(CHEMBL4084643)
Affinity DataIC50: 91nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240281(CHEMBL4086486)
Affinity DataIC50: 112nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240287(CHEMBL4094846)
Affinity DataIC50: 129nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240286(CHEMBL4065741)
Affinity DataIC50: 136nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240293(CHEMBL4073293)
Affinity DataIC50: 142nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240284(CHEMBL4100911)
Affinity DataIC50: 160nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240283(CHEMBL4082930)
Affinity DataIC50: 210nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240288(CHEMBL4074359)
Affinity DataIC50: 215nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240285(CHEMBL4087167)
Affinity DataIC50: 375nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240279(CHEMBL4080553)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240278(CHEMBL4062780)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 3.80E+3nMAssay Description:Antagonist activity at 5HT2B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240283(CHEMBL4082930)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240280(CHEMBL4065038)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at alpha2A-adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at human alpha2B-adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at alpha1D-adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50024250(CHEMBL2324000)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells at -140 mV holding potential measured for 8 secs by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240294(CHEMBL4100134)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240289(CHEMBL4102586)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240292(CHEMBL4092379)
Affinity DataIC50: 2.25E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240293(CHEMBL4073293)
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240287(CHEMBL4094846)
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240290(CHEMBL4084643)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240278(CHEMBL4062780)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240281(CHEMBL4086486)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240282(CHEMBL4090731)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240284(CHEMBL4100911)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240285(CHEMBL4087167)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240286(CHEMBL4065741)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240288(CHEMBL4074359)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
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