Compile Data Set for Download or QSAR
Report error Found 99 Enz. Inhib. hit(s) with all data for entry = 50049278
LigandPNGBDBM217933(US9212182, 674)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217798(US9212182, 1053)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217696(US9212182, 672)
Affinity DataIC50: 6nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as use-dependent block at pulse 26 after 3 to 8 mins by ionworks quattro electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217799(US9212182, 1054)
Affinity DataIC50: 7nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217725(US9212182, 652 | US9212182, 653 | US9212182, 654)
Affinity DataIC50: 7nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217447(US9212182, 540 | US9212182, 541)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217465(US9212182, 457 | US9212182, 458)
Affinity DataIC50: 9nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217656(US9212182, 658)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217481(US9212182, 469 | US9212182, 470)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217422(US9212182, 419 | US9212182, 420)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217457(US9212182, 475 | US9212182, 476)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217548(US9212182, 512 | US9212182, 513)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217758(US9212182, 696)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50237989(CHEMBL4084372)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217829(US9212182, 691)
Affinity DataIC50: 15nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217517(US9212182, 363 | US9212182, 364)
Affinity DataIC50: 17nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217817(US9212182, 683)
Affinity DataIC50: 17nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217889(US9212182, 632)
Affinity DataIC50: 18nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217872(US9212182, 673)
Affinity DataIC50: 19nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217696(US9212182, 672)
Affinity DataIC50: 21nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217431(US9212182, 423 | US9212182, 424)
Affinity DataIC50: 22nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217435(US9212182, 323 | US9212182, 324)
Affinity DataIC50: 23nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217426(US9212182, 359 | US9212182, 360)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217819(US9212182, 685)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217426(US9212182, 359 | US9212182, 360)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342945(US9776995, Example 299 | US9776995, Example 298 | ...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342945(US9776995, Example 299 | US9776995, Example 298 | ...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217818(US9212182, 684)
Affinity DataIC50: 27nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217696(US9212182, 672)
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells measured after 3 to 5 mins by patchXpress electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342945(US9776995, Example 299 | US9776995, Example 298 | ...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217701(US9212182, 955)
Affinity DataIC50: 69nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM217656(US9212182, 658)
Affinity DataIC50: 78nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM231435(US9346798, 182)
Affinity DataIC50: 120nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50237990(CHEMBL4069051)
Affinity DataIC50: 160nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM231476(US9346798, 223)
Affinity DataIC50: 210nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217458(US9212182, 463 | US9212182, 464)
Affinity DataIC50: 240nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM231435(US9346798, 182)
Affinity DataIC50: 250nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217463(US9212182, 455 | US9212182, 456)
Affinity DataIC50: 270nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217458(US9212182, 463 | US9212182, 464)
Affinity DataIC50: 500nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217458(US9212182, 463 | US9212182, 464)
Affinity DataIC50: 500nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM217701(US9212182, 955)
Affinity DataIC50: 510nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM342945(US9776995, Example 299 | US9776995, Example 298 | ...)
Affinity DataIC50: 560nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM342945(US9776995, Example 299 | US9776995, Example 298 | ...)
Affinity DataIC50: 560nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50237989(CHEMBL4084372)
Affinity DataIC50: 580nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM217426(US9212182, 359 | US9212182, 360)
Affinity DataIC50: 580nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM217426(US9212182, 359 | US9212182, 360)
Affinity DataIC50: 580nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM217696(US9212182, 672)
Affinity DataIC50: 650nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells assessed as use-dependent block at pulse 26 after 3 to 8 mins by ionworks quattro electrophysiol...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM217422(US9212182, 419 | US9212182, 420)
Affinity DataIC50: 850nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM217447(US9212182, 540 | US9212182, 541)
Affinity DataIC50: 880nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM217829(US9212182, 691)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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