Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50049197
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236213(2-(3-Benzylureido)Benzoic Acid | CHEMBL561499)
Affinity DataKd:  5.00E+5nMAssay Description:Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236214(CHEMBL4089211)
Affinity DataKd:  5.00E+5nMAssay Description:Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl...More data for this Ligand-Target Pair
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PubMed
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKallikrein-7(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of KLK7 (unknown origin)More data for this Ligand-Target Pair
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PubMed
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant human complement factor D catalytic domain (G24 to A253 residues) expressed in Escherichia coli Rosetta using Z-Lys-thioben...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236212(CHEMBL4093577)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of recombinant human complement factor D catalytic domain (G24 to A253 residues) expressed in Escherichia coli Rosetta using Z-Lys-thioben...More data for this Ligand-Target Pair
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PubMed
TargetKallikrein-5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human kallikrein 5More data for this Ligand-Target Pair
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PubMed
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50236211(CHEMBL4065974)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human complement factor D catalytic domain (G24 to A253 residues) expressed in Escherichia coli Rosetta using Z-Lys-thioben...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProthrombin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
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PubMed
TargetCoagulation factor X(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human coagulation factor 10aMore data for this Ligand-Target Pair
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PubMed
TargetNeutrophil elastase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203865(Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed