Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50006671
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50481119(AZD-2184 | CHEMBL570378)
Affinity DataKd:  8.40nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) fibrils after 3 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human amyloid beta (1 to 40) aggregation after 1 hr by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human amyloid beta (1 to 42) aggregation after 46 to 48 hrs by Thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM212434(Dihydromyricetin (diH-Myr) | (2R,3R)-3,5,7-trihydr...)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of recombinant amyloid beta (1 to 42) fibrils (unknown origin) by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM7462(cid_5280863 | CHEMBL150 | 3,5,7-trihydroxy-2-(4-hy...)
Affinity DataIC50: 7.51E+4nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataIC50: 1.76E+5nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50100134(Thioflavin T, 1 | 2-[4-(dimethylamino)phenyl]-3,6-...)
Affinity DataKi:  890nMAssay Description:Displacement of [N-methyl-11C]6-Me-BTA-1 from pre-aggregated amyloid beta (1 to 40) fibrils (unknown origin) after 30 mins by scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed