Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50047931
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataEC50:  2.20E+4nMAssay Description:Inhibition of NGF-induced TrkA auto-phosphorylation in rat PC12 cells incubated for 15 mins by chemiluminescence based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM164885(US9067914, Ex. 3-1 | US10166239, Ex. 3-1 | US11406...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal GST tagged human TrkA cytoplasmic domain (436 to 790 amino acids) pre-incubated for 15 mins before peptide substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM164885(US9067914, Ex. 3-1 | US10166239, Ex. 3-1 | US11406...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal GST tagged human TrkB cytoplasmic domain (456 to 822 amino acids) pre-incubated for 15 mins before peptide substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197620(CHEMBL3921392 | US9815846, Compound 49)
Affinity DataIC50: 4nMAssay Description:Inhibition of TrkA (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of TrkA (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 24nMAssay Description:Inhibition of TrkC (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 24nMAssay Description:Inhibition of TrkB (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197616(CHEMBL3930625)
Affinity DataIC50: 50nMAssay Description:Inhibition of NGF-stimulated TrkA phosphorylation in human U2OS cells by beta-galactosidase reporter gene based PathHunter profiling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197615(CHEMBL3939636)
Affinity DataIC50: 100nMAssay Description:Inhibition of His-tagged recombinant human TrkA using Alexa-Fluor tracer-236 incubated for 60 mins by TR-FRET based Lantha-screen Eu kinase binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197619(CHEMBL3911923)
Affinity DataIC50: 100nMAssay Description:Inhibition of His-tagged recombinant human TrkA using Alexa-Fluor tracer-236 incubated for 60 mins by TR-FRET based Lantha-screen Eu kinase binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197618(CHEMBL3901030)
Affinity DataIC50: 100nMAssay Description:Inhibition of His-tagged recombinant human TrkA using Alexa-Fluor tracer-236 incubated for 60 mins by TR-FRET based Lantha-screen Eu kinase binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197617(CHEMBL3953405)
Affinity DataIC50: 100nMAssay Description:Inhibition of His-tagged recombinant human TrkA using Alexa-Fluor tracer-236 incubated for 60 mins by TR-FRET based Lantha-screen Eu kinase binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM164885(US9067914, Ex. 3-1 | US10166239, Ex. 3-1 | US11406...)
Affinity DataIC50: 503nMAssay Description:Inhibition of N-terminal GST tagged human TrkC catalytic domain (456 to 825 amino acids) using fluorescence-labeled substrate by off-chip mobility sh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50: 5.88E+3nMAssay Description:Inhibition of binding of [125I]-NGF to TrkA in rat PC12 cells incubated for 2 hrs by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197616(CHEMBL3930625)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NT3-stimulated TrkC phosphorylation in human U2OS cells by beta-galactosidase reporter gene based PathHunter profiling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50197616(CHEMBL3930625)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BDNF-stimulated TrkB phosphorylation in human U2OS cells by beta-galactosidase reporter gene based PathHunter profiling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50396070(CHEMBL1397270)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of mouse NGF binding to TrkA (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029495(7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of mouse NGF binding to TrkA (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50029495(7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of mouse NGF binding to p75 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50: 1.49E+5nMAssay Description:Inhibition of mouse NGF binding to TrkA (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50396070(CHEMBL1397270)
Affinity DataIC50: 2.44E+5nMAssay Description:Inhibition of mouse NGF binding to p75 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of mouse NGF binding to p75 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed