Compile Data Set for Download or QSAR
Report error Found 75 Enz. Inhib. hit(s) with all data for entry = 50047839
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193032(CHEMBL3979343 | US11155556, No. 2)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193014(CHEMBL3942643 | US11155556, No. 9)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM150175(US8980901, 107 | US9149477, Compound 107)
Affinity DataIC50: 2nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193032(CHEMBL3979343 | US11155556, No. 2)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193030(CHEMBL3950648 | US11155556, No. 14)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193014(CHEMBL3942643 | US11155556, No. 9)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193023(CHEMBL3898901 | US11155556, No. 5)
Affinity DataIC50: 15nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193030(CHEMBL3950648 | US11155556, No. 14)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193024(CHEMBL3909068)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193030(CHEMBL3950648 | US11155556, No. 14)
Affinity DataIC50: 20nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193016(CHEMBL3889977 | US11155556, No. 3)
Affinity DataIC50: 20nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193024(CHEMBL3909068)
Affinity DataIC50: 23nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193023(CHEMBL3898901 | US11155556, No. 5)
Affinity DataIC50: 29nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193030(CHEMBL3950648 | US11155556, No. 14)
Affinity DataIC50: 30nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 39nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193021(CHEMBL3922919 | US11155556, No. 13)
Affinity DataIC50: 41nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193015(CHEMBL3918001 | US11155556, No. 4)
Affinity DataIC50: 49nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193012(CHEMBL3926951 | US11155556, No. 6)
Affinity DataIC50: 49nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193018(CHEMBL3986648 | US11155556, No. 10)
Affinity DataIC50: 51nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193032(CHEMBL3979343 | US11155556, No. 2)
Affinity DataIC50: 53nMAssay Description:Inhibition of human PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 55nMAssay Description:Inhibition of human PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193021(CHEMBL3922919 | US11155556, No. 13)
Affinity DataIC50: 58nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193032(CHEMBL3979343 | US11155556, No. 2)
Affinity DataIC50: 59nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM150175(US8980901, 107 | US9149477, Compound 107)
Affinity DataIC50: 64nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193014(CHEMBL3942643 | US11155556, No. 9)
Affinity DataIC50: 70nMAssay Description:Inhibition of human PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193029(CHEMBL3913941 | US11155556, No. 15)
Affinity DataIC50: 76nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193012(CHEMBL3926951 | US11155556, No. 6)
Affinity DataIC50: 80nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193012(CHEMBL3926951 | US11155556, No. 6)
Affinity DataIC50: 96nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193029(CHEMBL3913941 | US11155556, No. 15)
Affinity DataIC50: 110nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193024(CHEMBL3909068)
Affinity DataIC50: 110nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193014(CHEMBL3942643 | US11155556, No. 9)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193032(CHEMBL3979343 | US11155556, No. 2)
Affinity DataIC50: 120nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193015(CHEMBL3918001 | US11155556, No. 4)
Affinity DataIC50: 120nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193014(CHEMBL3942643 | US11155556, No. 9)
Affinity DataIC50: 120nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193016(CHEMBL3889977 | US11155556, No. 3)
Affinity DataIC50: 120nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 130nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 150nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 150nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
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