Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50000984
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50336576(3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-...)
Affinity DataKd:  58nMAssay Description:Inhibition of FAM-Bid binding to Mcl-1 (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50336576(3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-...)
Affinity DataKd:  310nMAssay Description:Inhibition of FAM-Bid binding to Bcl-2 (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50030764(CHEMBL3342187)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of biotinylated BIM BH3 26-mer peptide binding to GST-tagged Bcl-xL (unknown origin) pre-incubated for 30 mins followed by peptide additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of FITC-labeled Bim BH3 binding to GST-tagged Mcl-1 (unknown origin) preincubated for 2 mins followed by FITC-Bim-BH3 addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 31nMAssay Description:Inhibition of FITC-labeled Bim BH3 binding to GST-tagged Bcl-2 (unknown origin) preincubated for 2 mins followed by FITC-Bim-BH3 addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 76nMAssay Description:Inhibition of FITC-labeled Bak-BH3 binding to GST-tagged Bcl-xL (unknown origin) preincubated for 5 mins followed by FITC-Bak-BH3 addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 122nMAssay Description:Inhibition of FITC-labeled Bim BH3 binding to GST-tagged Bcl2A1 (unknown origin) preincubated for 2 mins followed by FITC-Bim-BH3 addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50266958(CHEMBL4077940)
Affinity DataIC50: 394nMAssay Description:Inhibition of FITC-labeled Bak-BH3 peptide binding to Bcl-xL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50266957(CHEMBL2070024)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Bak BH3 peptide binding to GST-tagged human Bcl-xL after 3 hrs by Western blotting-based GST pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM380478(US9926306, ID 183-84)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of FITC-BID BH3 peptide binding to recombinant GST-tagged N-terminal/C-terminal truncated Mcl-1 (unknown origin) expressed in Escherichia ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50266957(CHEMBL2070024)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of Bim BH3 peptide binding to GST-tagged human Mcl-1 after 3 hrs by Western blotting-based GST pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50266958(CHEMBL4077940)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FITC-labeled Bak-BH3 peptide binding to Mcl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50266967(CHEMBL3393621 | CHEBI:66678)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of biotinylated Bim BH3 peptide binding to GST-tagged mouse Mcl-1 expressed in Escherichia coli BL21 (DE3) pre-incubated for 1 hr followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM380478(US9926306, ID 183-84)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FITC-BID BH3 peptide binding to recombinant GST-tagged C-terminal truncated Bcl-xL (unknown origin) expressed in Escherichia coli BL21 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50266959(CHEMBL4085804)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50266959(CHEMBL4085804)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-w (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  48nMAssay Description:Binding affinity to Bcl-xL (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM31406(terphenyl scaffold, 14)
Affinity DataKi:  114nMAssay Description:Inhibition of fluorescein-labeled 16-mer Bak peptide binding to Bcl-xL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  245nMAssay Description:Binding affinity to Bcl-w (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi: >444nMAssay Description:Binding affinity to Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity to Bcl2A1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity to Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed