Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50047995
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200465(CHEMBL3975863)
Affinity DataKd:  355nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS by SPR-based solution com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200467(CHEMBL3899754)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to mouse Keap1 Kelch domain expressed in Escherichia coli BL21 by VP-ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006933(CHEMBL3134422)
Affinity DataKd:  21nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS by SPR-based solution com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200466(CHEMBL3913014)
Affinity DataKd:  10nMAssay Description:Binding affinity to Keap1 (unknown origin) Kelch domain by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200472(CHEMBL3966742)
Affinity DataKd:  26nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS by fluorescence polarizat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200464(CHEMBL3982888)
Affinity DataKd:  47nMAssay Description:Binding affinity to Keap1 (unknown origin) Kelch domain by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200469(CHEMBL3946551)
Affinity DataKd:  96nMAssay Description:Binding affinity to His-tagged Keap1 (unknown origin) Kelch domain expressed in Escherichia coli BL21(DE3) pLysS by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200466(CHEMBL3913014)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of Keap1 Kelch domain (unknown origin) interaction with Nrf2 assessed as displacement of FITC-betaAla-DEETGEF-OH from Keap1 Kelch domain b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200461(CHEMBL3946369)
Affinity DataIC50: 22nMAssay Description:Inhibition of Keap1/Nrf2 (unknown origin) interaction assessed as displacement of FITC-betaAla-DEETGEF-OH from Keap1 Kelch domain after 1 hr by FITC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200464(CHEMBL3982888)
Affinity DataIC50: 30nMAssay Description:Inhibition of Keap1 Kelch domain (unknown origin) interaction with Nrf2 assessed as displacement of FITC-betaAla-DEETGEF-OH from Keap1 Kelch domain b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200470(CHEMBL3965115)
Affinity DataIC50: 43nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS by SPR-based solution com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200462(CHEMBL3928693)
Affinity DataIC50: 115nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli interaction with Nrf2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50006933(CHEMBL3134422)
Affinity DataIC50: 194nMAssay Description:Inhibition of recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS interaction with Nrf2 assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200473(CHEMBL3908796)
Affinity DataIC50: 248nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli interaction with Nrf2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200474(CHEMBL3965182)
Affinity DataIC50: 634nMAssay Description:Inhibition of Keap1/Nrf2 (unknown origin) interaction assessed as displacement of FITC-betaAla-DEETGEF-OH from Keap1 Kelch domain after 1 hr by FITC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200471(CHEMBL3970907)
Affinity DataIC50: 730nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli interaction with Nrf2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200460(CHEMBL3890847)
Affinity DataIC50: 750nMAssay Description:Inhibition of recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS/Nrf2-ETGE peptide interaction a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear factor erythroid 2-related factor 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200468(CHEMBL3919787)
Affinity DataIC50: 875nMAssay Description:Inhibition of Keap1/Nrf2 (unknown origin) interaction assessed as displacement of FITC-betaAla-DEETGEF-OH from Keap1 Kelch domain after 1 hr by FITC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200465(CHEMBL3975863)
Affinity DataIC50: 3.57E+3nMAssay Description:Inhibition of recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS interaction with Nrf2 assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50200463(CHEMBL3967367)
Affinity DataIC50: 5.39E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli interaction with Nrf2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2018
Entry Details Article
PubMed