Compile Data Set for Download or QSAR
Report error Found 70 Enz. Inhib. hit(s) with all data for entry = 50018895
TargetRibosomal protein S6 kinase alpha-1(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataKd:  3.55E+3nMAssay Description:Binding affinity to human RSK1 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50613680(CHEMBL5285509)
Affinity DataKd:  1.74E+3nMAssay Description:Binding affinity to human recombinant BRD4 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataKd:  3.42E+3nMAssay Description:Binding affinity to human N-terminal His6-tagged BRDTexpressed in Escherichia coli BL21 (DE3) cells (21 to 137 residues) incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11643396, Example TG101209 | US112797...)
Affinity DataKd:  123nMAssay Description:Binding affinity to human N-terminal His6-tagged BRDTexpressed in Escherichia coli BL21 (DE3) cells (21 to 137 residues) incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  164nMAssay Description:Binding affinity to human N-terminal His6-tagged BRDTexpressed in Escherichia coli BL21 (DE3) cells (21 to 137 residues) incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50613682(CHEMBL5276995)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50613682(CHEMBL5276995)
Affinity DataIC50: 5nMAssay Description:Inhibition of PLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM26479(4-N-(3-methyl-1H-indazol-6-yl)-2-N-(3,4,5-trimetho...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11643396, Example TG101209 | US112797...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50613680(CHEMBL5285509)
Affinity DataIC50: 8nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 9nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 11nMAssay Description:Inhibition of PYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 11(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50099349(2-(2,3-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 15nMAssay Description:Inhibition of RSK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50099349(2-(2,3-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 17nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11643396, Example TG101209 | US112797...)
Affinity DataIC50: 17nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 17nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human RSK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 18nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 24nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 25nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50099334(4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50: 25nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 11(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50099334(4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50: 25nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427457(CHEMBL2326952 | US9505780, 25 | US10308662, Compou...)
Affinity DataIC50: 27nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant full-length GSK3alpha expressed in Escherichia coli incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM25017(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Affinity DataIC50: 31nMAssay Description:Inhibition of RSK1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 32nMAssay Description:Inhibition of BRD2/3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 35nMAssay Description:Inhibition of BRDT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50613683(CHEMBL5270270)
Affinity DataIC50: 44nMAssay Description:Inhibition of EGFR (unknown origin) using flurogenic substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50: 50nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50613682(CHEMBL5276995)
Affinity DataIC50: 56nMAssay Description:Inhibition of PLK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50: 94nMAssay Description:Inhibition of human recombinant full-length GSK3beta expressed in Escherichia coli incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 11(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50: 100nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50613680(CHEMBL5285509)
Affinity DataIC50: 100nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11643396, Example TG101209 | US112797...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human N-terminal His6-tagged BRDT (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 158nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11643396, Example TG101209 | US112797...)
Affinity DataIC50: 169nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 280nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human N-terminal His6-tagged BRDT (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
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