Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 50009852
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 0.251nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 0.251nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic sur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic sur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: 0.501nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: 0.501nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50: 1.30nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50: 1.30nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519345(CHEMBL4447844)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human DAGLalpha expressed in HEK293T cell membrane fractions using PNP butyrate as substrate preincubated for 20 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519345(CHEMBL4447844)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human DAGLalpha expressed in HEK293T cell membrane fractions using PNP butyrate as substrate preincubated for 20 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 4nMAssay Description:Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 4nMAssay Description:Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50: 5nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50: 5nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532885(CHEMBL4470017)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human GST-tagged DAGLbeta catalytic domain expressed in HEK293F cell membranes using EnzChek as substrate preincubated for 5 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532885(CHEMBL4470017)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human GST-tagged DAGLbeta catalytic domain expressed in HEK293F cell membranes using EnzChek as substrate preincubated for 5 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of mouse DAGLbeta expressed in HEK293T cell membranes using SAG as substrate preincubated for 30 mins followed by substrate addition by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of mouse DAGLbeta expressed in HEK293T cell membranes using SAG as substrate preincubated for 30 mins followed by substrate addition by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519345(CHEMBL4447844)
Affinity DataIC50: 13nMAssay Description:Inhibition of DAGLalpha (unknown origin) by natural substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519345(CHEMBL4447844)
Affinity DataIC50: 13nMAssay Description:Inhibition of DAGLalpha (unknown origin) by natural substrate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 25nMAssay Description:Inhibition of human GST-tagged DAGLbeta catalytic domain expressed in HEK293F cell membranes using EnzChek as substrate preincubated for 5 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519345(CHEMBL4447844)
Affinity DataIC50: 25nMAssay Description:Inhibition of DAGLalpha in mouse brain proteome pre-incubated for 30 mins followed by ABP MB064 probe addition for 15 mins by ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211236(CHEMBL2144065)
Affinity DataIC50: 25nMAssay Description:Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 25nMAssay Description:Inhibition of human GST-tagged DAGLbeta catalytic domain expressed in HEK293F cell membranes using EnzChek as substrate preincubated for 5 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211236(CHEMBL2144065)
Affinity DataIC50: 25nMAssay Description:Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519345(CHEMBL4447844)
Affinity DataIC50: 25nMAssay Description:Inhibition of DAGLalpha in mouse brain proteome pre-incubated for 30 mins followed by ABP MB064 probe addition for 15 mins by ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211236(CHEMBL2144065)
Affinity DataIC50: 40nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50161518(1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human DAGLalpha expressed in HEK293T cell membrane fractions using PNP butyrate as substrate preincubated for 20 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50161518(1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human DAGLalpha expressed in HEK293T cell membrane fractions using PNP butyrate as substrate preincubated for 20 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211236(CHEMBL2144065)
Affinity DataIC50: 40nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 63nMAssay Description:Inhibition of full length V5 tagged human DAGLalpha expressed in African green monkey COS7 cells using sn-1-stearoyl-[14C]-arachidonoyl-glycerol as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 63nMAssay Description:Inhibition of full length V5 tagged human DAGLalpha expressed in African green monkey COS7 cells using sn-1-stearoyl-[14C]-arachidonoyl-glycerol as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532883(CHEMBL2136920)
Affinity DataIC50: 63nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532883(CHEMBL2136920)
Affinity DataIC50: 63nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211236(CHEMBL2144065)
Affinity DataIC50: 79nMAssay Description:Inhibition of V-tagged mouse DAGLbeta expressed in HEK2934T cell membrane fractions using SAG as substrate assessed as accumulation of 2-AG preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532883(CHEMBL2136920)
Affinity DataIC50: 79nMAssay Description:Inhibition of V-tagged mouse DAGLbeta expressed in HEK2934T cell membrane fractions using SAG as substrate assessed as accumulation of 2-AG preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532883(CHEMBL2136920)
Affinity DataIC50: 79nMAssay Description:Inhibition of V-tagged mouse DAGLbeta expressed in HEK2934T cell membrane fractions using SAG as substrate assessed as accumulation of 2-AG preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211236(CHEMBL2144065)
Affinity DataIC50: 79nMAssay Description:Inhibition of V-tagged mouse DAGLbeta expressed in HEK2934T cell membrane fractions using SAG as substrate assessed as accumulation of 2-AG preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 100nMAssay Description:Inhibition of full length 3' FLAG-tagged mouse DAGLbeta expressed in African green monkey COS7 cells using sn-1-stearoyl-[14C]-arachidonoyl-glycerol ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 100nMAssay Description:Inhibition of full length 3' FLAG-tagged mouse DAGLbeta expressed in African green monkey COS7 cells using sn-1-stearoyl-[14C]-arachidonoyl-glycerol ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532883(CHEMBL2136920)
Affinity DataIC50: 126nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048620(CHEMBL3319620)
Affinity DataIC50: 126nMAssay Description:Inhibition of DAGLalpha in mouse brain proteome pre-incubated for 30 mins followed by ABP MB064 probe addition for 15 mins by ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532883(CHEMBL2136920)
Affinity DataIC50: 126nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048620(CHEMBL3319620)
Affinity DataIC50: 126nMAssay Description:Inhibition of DAGLalpha in mouse brain proteome pre-incubated for 30 mins followed by ABP MB064 probe addition for 15 mins by ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 251nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 251nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50161518(1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one...)
Affinity DataIC50: 501nMAssay Description:Inhibition of DAGLalpha in mouse brain proteome pre-incubated for 30 mins followed by ABP MB064 probe addition for 15 mins by ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50161518(1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one...)
Affinity DataIC50: 501nMAssay Description:Inhibition of DAGLalpha in mouse brain proteome pre-incubated for 30 mins followed by ABP MB064 probe addition for 15 mins by ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Displayed 1 to 50 (of 64 total ) | Next | Last >>
Jump to: