Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50047817
TargetcGMP-dependent protein kinase 1(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to human recombinant N-terminal GST-tagged PKGalpha expressed in Baculovirus infected insect Sf9 cells using RKRSRAE as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKd:  6.40nMAssay Description:Binding affinity to PKCalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to PKCbeta2 (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to PKAalpha (unknown origin) using Lys-Arg-Thr-Leu-Arg-Arg as substrate after 8 mins in presence of [gamma-32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 440nMAssay Description:Inhibition of bovine C-terminal truncated GRK5 (561 residues) assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 2(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191311(CHEMBL3950887)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant bovine GRK3 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191311(CHEMBL3950887)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant human GRK5 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191319(CHEMBL3942164)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human GRK5 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191313(CHEMBL3931500)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of recombinant human GRK5 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of bovine C-terminal truncated GRK1 (535 residues) assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 2(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191313(CHEMBL3931500)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of recombinant bovine GRK3 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191326(CHEMBL3953837)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of recombinant human GRK5 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191310(CHEMBL3971763)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of recombinant human GRK5 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 2(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191319(CHEMBL3942164)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of recombinant bovine GRK3 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191320(CHEMBL3945401)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of bovine cerebral cortex GRK2 assessed as decrease in rhodopsin phosphorylation by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 2(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191326(CHEMBL3953837)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of recombinant bovine GRK3 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 2(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191312(CHEMBL3900757)
Affinity DataIC50: 3.04E+4nMAssay Description:Inhibition of recombinant bovine GRK3 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM14056(N-(7-chloro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of bovine GRK5 assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191324(CHEMBL3910956)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of bovine cerebral cortex GRK2 assessed as decrease in phosphorylation of beta-adrenoceptor in presence of [gamma-32P]-ATP by SDS-PAGE ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 2(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191310(CHEMBL3971763)
Affinity DataIC50: 5.55E+4nMAssay Description:Inhibition of recombinant bovine GRK3 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191312(CHEMBL3900757)
Affinity DataIC50: 6.13E+4nMAssay Description:Inhibition of recombinant human GRK5 expressed in Sf9 insect cells assessed as decrease in phosphorylation of urea-washed bovine rod outer segments i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191322(CHEMBL3928291)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of bovine cerebral cortex GRK2 assessed as decrease in phosphorylation of beta-adrenoceptor in presence of [gamma-32P]-ATP by SDS-PAGE ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM14052(N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6...)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of bovine GRK5 assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM14051(4-(3,4-Dichlorophenyl)-N-1H-indazol-5-yl-2-methyl-...)
Affinity DataIC50: 7.94E+4nMAssay Description:Inhibition of bovine GRK5 assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50173320(GSK-180736A | GSK180736A | US10023564, Compound GS...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of bovine GRK5 assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50331515(PAROXETINE | Paxil | CHEMBL1708 | Paxil cr | Parox...)
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of C-terminal hexahistidine tagged bovine GRK5 (561 residues) assessed as decrease in phosphorylation of tubulin preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50331515(PAROXETINE | Paxil | CHEMBL1708 | Paxil cr | Parox...)
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of bovine GRK5 assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50331515(PAROXETINE | Paxil | CHEMBL1708 | Paxil cr | Parox...)
Affinity DataIC50: 1.58E+5nMAssay Description:Inhibition of C-terminal hexahistidine tagged bovine GRK1 (535 residues) assessed as decrease in phosphorylation of tubulin preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein kinase C alpha type(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50331515(PAROXETINE | Paxil | CHEMBL1708 | Paxil cr | Parox...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST tagged PKCalpha expressed in Baculovirus infected Sf9 insect cells using KRREILSRRPSYR as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50331515(PAROXETINE | Paxil | CHEMBL1708 | Paxil cr | Parox...)
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of C-terminal hexahistidine tagged bovine GRK5 (561 residues) assessed as decrease in phosphorylation of light-activated bovine rod outer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50331515(PAROXETINE | Paxil | CHEMBL1708 | Paxil cr | Parox...)
Affinity DataIC50: 3.16E+5nMAssay Description:Inhibition of C-terminal hexahistidine tagged bovine GRK1 (535 residues) assessed as decrease in phosphorylation of light-activated bovine rod outer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRhodopsin kinase GRK1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50331515(PAROXETINE | Paxil | CHEMBL1708 | Paxil cr | Parox...)
Affinity DataIC50: 3.98E+5nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetG protein-coupled receptor kinase 5(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191325(CHEMBL3918278)
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of bovine GRK5 assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM14052(N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6...)
Affinity DataIC50: 7.94E+5nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50173320(GSK-180736A | GSK180736A | US10023564, Compound GS...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191323(CHEMBL3959608)
Affinity DataIC50: 3.60E+6nMAssay Description:Inhibition of bovine cerebral cortex GRK2 assessed as decrease in rhodopsin phosphorylation by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM14056(N-(7-chloro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191315(CHEMBL3900347)
Affinity DataIC50: 1.60E+6nMAssay Description:Inhibition of bovine cerebral cortex GRK2 assessed as decrease in phosphorylation of beta-adrenoceptor in presence of [gamma-32P]-ATP by SDS-PAGE ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191325(CHEMBL3918278)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM14051(4-(3,4-Dichlorophenyl)-N-1H-indazol-5-yl-2-methyl-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50191309(CHEMBL3919384)
Affinity DataIC50: 2.60E+6nMAssay Description:Inhibition of bovine cerebral cortex GRK2 assessed as decrease in phosphorylation of beta-adrenoceptor in presence of [gamma-32P]-ATP by SDS-PAGE ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2018
Entry Details Article
PubMed