Compile Data Set for Download or QSAR
Report error Found 164 Enz. Inhib. hit(s) with all data for entry = 50047845
TargetCyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataKd:  4.10nMAssay Description:Binding affinity to full length human CDK9 (1 to 372 residues) expressed in bacterial expression system by KINOMEscan competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 7(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to full length human CDK7 (1 to 344 residues) expressed in mammalian expression system by KINOMEscan competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataKd:  540nMAssay Description:Binding affinity to full length human CDK2 (1 to 298 residues) expressed in bacterial expression system by KINOMEscan competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193087(CHEMBL3897452)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193096(CHEMBL3977324)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using cdk7tide peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK5 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated Histone H1 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK2 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated Histone H1 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK5/p25 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated histone H1 as substrate aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated histone H1 as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193087(CHEMBL3897452)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193103(CHEMBL3957795)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant full length His-tagged CDK9/cyclin T1 expressed in insect cells using biotin-Ttds-YISPLKSPYKISEG as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193087(CHEMBL3897452)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK4/cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM179848(US9669034, 113 (rac)-[Cyclopropyl(3-{[4-(4-fluoro-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant full length His-tagged CDK9/cyclin T1 expressed in insect cells using biotin-Ttds-YISPLKSPYKISEG as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193092(CHEMBL3948080)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using cdk7tide peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant CDK4/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK7/cyclin H (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK3/cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM170515(US9669034, 90 (rac)-4-{4-Fluoro-2-[(3-fluorobenzyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant full length His-tagged CDK9/cyclin T1 expressed in insect cells using biotin-Ttds-YISPLKSPYKISEG as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193101(CHEMBL3896233)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human His6-tagged CDK9/cyclin T1 expressed in baculovirus infected sf9 cells using GST-CTD as substrate after 10 mins in presence of [g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human His6-tagged CDK9/cyclin T1 expressed in baculovirus infected sf9 cells using GST-CTD as substrate after 10 mins in presence of [g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193109(CHEMBL3924246)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human His6-tagged CDK9/cyclin T1 expressed in baculovirus infected sf9 cells using GST-CTD as substrate after 10 mins in presence of [g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 3nMAssay Description:Inhibition of human GST-tagged CDK9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK3/N-terminal GST-tagged cyclin E expressed in baculovirus infected Sf21 insect ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant CDK1/cyclin B (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated histone H1 as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM164883(US9067888, 33)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using cdk7tide peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 3nMAssay Description:Inhibition of human GST-tagged CDK5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193102(CHEMBL3921344)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant full length His-tagged CDK9/cyclin T1 expressed in insect cells using biotin-Ttds-YISPLKSPYKISEG as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant CDK1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated Histone H1 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant CDK2/cyclin A after 30 mins by [gamma-33P]ATP based scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant CDK5/p25 expressed in baculovirus infected Sf9 insect cells after 30 mins by [gamma-33P]ATP based scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK7/cyclin H/N-terminal GST-tagged MAT1 expressed in baculovirus infected Sf21 in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant CDK9/cyclin T (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated histone H1 as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK9/cyclin T1 expressed in baculovirus infected Sf21 insect cells using PDKtide a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant CDK9 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated Histone H1 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193094(CHEMBL3930310)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant full length His-tagged CDK9/cyclin T1 expressed in insect cells using biotin-Ttds-YISPLKSPYKISEG as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM106950(US8592581, 1)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193085(CHEMBL3925525)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK9/cyclin T1 expressed in baculovirus infected Sf21 insect cells using PDKtide a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193099(CHEMBL3915260)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human His6-tagged CDK9/cyclin T1 expressed in baculovirus infected sf9 cells using GST-CTD as substrate after 10 mins in presence of [g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50371400(MERIOLIN 5)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus infected Sf9 insect cells using pRB (773 to 928 residues) as substrate after 3...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50371402(MERIOLIN 3)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus infected Sf9 insect cells using pRB (773 to 928 residues) as substrate after 3...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193089(CHEMBL3976972)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human His6-tagged CDK9/cyclin T1 expressed in baculovirus infected sf9 cells using GST-CTD as substrate after 10 mins in presence of [g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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