Compile Data Set for Download or QSAR
Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 50047419
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166601(CHEMBL3798679)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166602(CHEMBL3800310)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C beta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCbeta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCalpha (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCdelta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST-tagged human TrkA expressed in baculovirus preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST-tagged GSK-3beta (unknown origin) expressed in baculovirus preincubated for 5 mins using GSK3 substrate peptide measured...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 10nMAssay Description:Inhibition of CLK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 11nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50163919(CHEMBL3798266)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166601(CHEMBL3798679)
Affinity DataIC50: 16nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164188(CHEMBL3799399)
Affinity DataIC50: 45nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164176(CHEMBL3798713)
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFocal adhesion kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal FLAG-tagged FAK cytoplasmic domain (unknown origin) expressed in baculovirus preincubated for 5 mins measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 100nMAssay Description:Inhibition of full length N-terminal His-tagged recombinant human SRC preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScree...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human c-Met preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166599(CHEMBL3800082)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164291(CHEMBL3798849)
Affinity DataIC50: 150nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164191(CHEMBL3798787)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166602(CHEMBL3800310)
Affinity DataIC50: 170nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166600(CHEMBL3799887)
Affinity DataIC50: 240nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164166(CHEMBL3798933)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164293(CHEMBL3800116)
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164292(CHEMBL3798888)
Affinity DataIC50: 930nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged PI3Kalpha (unknown origin) co-expressed with p85alpha in baculovirus using L-alpha-phosphatidyl-D-myo-inositol 4...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human ROCK1 expressed in baculovirus preincubated for 5 mins using long S6 peptide as substrate measured after 10...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human EphA5 catalytic domain expressed in baculovirus preincubated for 5 mins measured after 10 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IRK (unknown origin) preincubated for 5 mins measured after 60 mins in presence of ATP by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal 6His-tagged CDK2/N-terminal GST-tagged cyclin A (unknown origin) expressed in baculovirus preincubated for 5 mins using hist...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C zeta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCzeta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged p38alpha (unknown origin) expressed in baculovirus preincubated for 5 mins using myelin basic protein as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164166(CHEMBL3798933)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged Aurora-B (unknown origin) preincubated for 5 mins using Aurora substrate peptide as substrate measured after 60 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164191(CHEMBL3798787)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged PLK1 (unknown origin) expressed in baculovirus preincubated for 5 mins using alpha-casein as substrate measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length human CDC7 co-expressed with N-terminal GST-tagged ASK in baculovirus preincubated for 5 mins using MCM2 as substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164293(CHEMBL3800116)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged VEGFR2 cytoplasmic domain (unknown origin) expressed in baculovirus preincubated for 5 mins measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged ERK1 (unknown origin) expressed in baculovirus preincubated for 5 mins using myelin basic protein as substrate m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human JAK1 expressed in baculovirus preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human IRAK4 expressed in baculovirus preincubated for 5 mins using myelin basic protein as substrate measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged MEK1 (unknown origin) expressed in freestyle293 system preincubated for 5 mins using GST-tagged ERK1 K71A as subs...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged MAPKAPK2 (unknown origin) expressed in baculovirus preincubated for 5 mins using KKLNRTLSVA-NH2 as substrate mea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged CHK1 (unknown origin) expressed in baculovirus preincubated for 5 mins using CHKtide as substrate measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged ASK1 (unknown origin) expressed in baculovirus preincubated for 5 mins using myelin basic protein as substrate m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase I isoform delta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged CK1delta (unknown origin) expressed in Escherichia coli preincubated for 5 mins using CK1tide as substrate measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50164188(CHEMBL3799399)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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