Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50047536
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173271(US9096596, 107 | US9096596, 23 | US9604982, Exampl...)
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173348(US9096596, 66 | US9604982, Example 66 | US10323032...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173348(US9096596, 66 | US9604982, Example 66 | US10323032...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173255(US9096596, 7 | US9604982, Example 7 | US10323032, ...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173260(US9096596, 12 | US9604982, Example 12 | US10323032...)
Affinity DataIC50: 28nMAssay Description:Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173255(US9096596, 7 | US9604982, Example 7 | US10323032, ...)
Affinity DataIC50: 489nMAssay Description:Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173255(US9096596, 7 | US9604982, Example 7 | US10323032, ...)
Affinity DataIC50: 562nMAssay Description:Antagonist activity against ATP-gated P2X7 receptor in LPS-stimulated human whole blood assessed as reduction in P2X7 agonist 2'(3')-O-(4-benzoylbenz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173271(US9096596, 107 | US9096596, 23 | US9604982, Exampl...)
Affinity DataIC50: 1.12E+3nMAssay Description:Antagonist activity against ATP-gated P2X7 receptor in LPS-stimulated human whole blood assessed as reduction in P2X7 agonist 2'(3')-O-(4-benzoylbenz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50173582(CHEMBL3810255)
Affinity DataIC50: 1.16E+3nMAssay Description:Antagonist activity against human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50173582(CHEMBL3810255)
Affinity DataIC50: 1.46E+3nMAssay Description:Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173260(US9096596, 12 | US9604982, Example 12 | US10323032...)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity against ATP-gated P2X7 receptor in LPS-stimulated human whole blood assessed as reduction in P2X7 agonist 2'(3')-O-(4-benzoylbenz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173271(US9096596, 107 | US9096596, 23 | US9604982, Exampl...)
Affinity DataIC50: 2.48E+3nMAssay Description:Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173260(US9096596, 12 | US9604982, Example 12 | US10323032...)
Affinity DataIC50: 5.97E+3nMAssay Description:Antagonist activity against rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells assessed as reduction in BzATP -induced Ca2+ flux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173271(US9096596, 107 | US9096596, 23 | US9604982, Exampl...)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173255(US9096596, 7 | US9604982, Example 7 | US10323032, ...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173255(US9096596, 7 | US9604982, Example 7 | US10323032, ...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]A-804598 from rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173271(US9096596, 107 | US9096596, 23 | US9604982, Exampl...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]A-804598 from rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173348(US9096596, 66 | US9604982, Example 66 | US10323032...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173260(US9096596, 12 | US9604982, Example 12 | US10323032...)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]A-804598 from rat recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM173260(US9096596, 12 | US9604982, Example 12 | US10323032...)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]A-804598 from human recombinant ATP-gated P2X7 receptor expressed in human 1321N1 cells after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed