Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50006483
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50444549(CHEMBL3099695)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500190(CHEMBL3746080)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500191(CHEMBL3747584)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500189(CHEMBL3746175)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500187(CHEMBL3747269)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50444549(CHEMBL3099695)
Affinity DataIC50: 2.5nMAssay Description:Inhibition human recombinant CYP11B1 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500185(CHEMBL3746125)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500188(CHEMBL3747562)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500187(CHEMBL3747269)
Affinity DataIC50: 4nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500188(CHEMBL3747562)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500190(CHEMBL3746080)
Affinity DataIC50: 7nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500191(CHEMBL3747584)
Affinity DataIC50: 9nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500186(CHEMBL3747069)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500184(CHEMBL3746868)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500186(CHEMBL3747069)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500185(CHEMBL3746125)
Affinity DataIC50: 21nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500183(CHEMBL3747503)
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500189(CHEMBL3746175)
Affinity DataIC50: 39nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500184(CHEMBL3746868)
Affinity DataIC50: 90nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500183(CHEMBL3747503)
Affinity DataIC50: 169nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500187(CHEMBL3747269)
Affinity DataIC50: 210nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500192(CHEMBL3746924)
Affinity DataIC50: 380nMAssay Description:Inhibition of CYP11B2 in human H285R cells assessed as decrease in [125I] angiotensin-2-induced aldosterone secretion after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Rat)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500189(CHEMBL3746175)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAromatase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500188(CHEMBL3747562)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human CYP19 preincubated for 10 mins with NADPH followed by protein addition measured after 90 mins by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Rat)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500185(CHEMBL3746125)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Rat)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500187(CHEMBL3747269)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500189(CHEMBL3746175)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Rat)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500184(CHEMBL3746868)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Rat)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500188(CHEMBL3747562)
Affinity DataIC50: 2.74E+4nMAssay Description:Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Rat)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50500186(CHEMBL3747069)
Affinity DataIC50: 5.31E+4nMAssay Description:Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed