Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50047235
Affinity DataIC50: 5.70nMAssay Description:Inhibition of TLR4 in LPS/INFgamma stimulated mouse peritoneal macrophages assessed as inhibition of IL1-beta after 20 hrs by ELISA analysisMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 7.5nMAssay Description:Inhibition of NLRP3 in mouse BMDM cells preincubated for 30 mins followed by ATP addition by ELISA analysisMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Reversible inhibition of NLRP3 in LPS activated human monocytes after 30 mins by ELISA analysis in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Irreversible inhibition of GSTO 1-1 in LPS activated human monocytes after 30 mins by ELISA analysis in presence of ATPMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Reversible inhibition of NLRP3 in LPS activated human monocytes after 30 mins by ELISA analysis in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Irreversible inhibition of GSTO 1-1 in LPS activated human monocytes after 30 mins by ELISA analysis in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of caspase-1 in LPS stimulated human PMBC cells after 2 hrs by ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 670nMAssay Description:Inhibition of caspase-1 in LPS stimulated human PMBC cells after 2 hrs by ELISA analysisMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of NLRP3 in LPS stimulated mouse BMDM cells after 15 mins followed by addition of ATP by ELISA analysisMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of NLRP3 in LPS stimulated human THP1 cells assessed as reduction in IL1beta release after 2 hrs by ELISA analysisMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of NLRP3 in mouse J774 macrophages assessed as reduction in Bacillus anthracis lethal toxin induced cell deathMore data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of NLRP3 in LPS activated human monocytes after 30 mins by ELISA analysis in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+5nMAssay Description:Binding affinity to pannexin 1 channel (unknown origin)More data for this Ligand-Target Pair
