Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50047159
TargetMelatonin receptor type 1A(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50114703(N-[2-(5-Methoxy-2-phenyl-benzofuran-3-yl)-ethyl]-a...)
Affinity DataKi:  0.0100nMAssay Description:Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50114703(N-[2-(5-Methoxy-2-phenyl-benzofuran-3-yl)-ethyl]-a...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50114716(N-[2-(2-Benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-a...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM21367(CHEMBL225284 | 6-{4-[2-(methylsulfanyl)phenyl]pipe...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to human mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50150940(CHEMBL3774617)
Affinity DataIC50: 0.360nMAssay Description:Displacement of [3H]BK from cloned human B2 bradykinin receptor expressed in CHO cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50146899(4-((E)-2-{[({2,4-Dichloro-3-[2-methyl-4-(pyridin-2...)
Affinity DataIC50: 0.410nMAssay Description:Displacement of [3H]BK from cloned human B2 bradykinin receptor expressed in CHO cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50150945(CHEBI:81390 | Immepip)
Affinity DataKi:  0.479nMAssay Description:Displacement of [3H]-NR-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataKi:  0.530nMAssay Description:Binding affinity to human mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50199326(N-butyloxycarbonyl-2-(4-imidazol-1-ylmethylphenyl)...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to angiotensin II receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50067281(CHEMBL439737 | CHEMBL542096 | 4-{(E)-2-[({[2,4-Dic...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]BK from cloned human B2 bradykinin receptor expressed in CHO cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50114716(N-[2-(2-Benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-a...)
Affinity DataKi:  1.30nMAssay Description:Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50147740(1-(1-Cyclooctyl-piperidin-4-yl)-1,3-dihydro-indol-...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]N/OFQ from human nociceptin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM21221(2-Cl-IB-MECA | CHEMBL431733 | C-IBzA-MU | 2-chloro...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to Adenosine receptor A3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetType-2 angiotensin II receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50049195(L-162389 | 3-[(2'-(butylsulfonylcarbamate)-3'-prop...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to angiotensin II receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50088421((2R,3R,4S,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-p...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to Adenosine receptor A3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to Adenosine receptor A3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMelanocortin receptor 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50138301(4-[(S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phen...)
Affinity DataKi:  2nMAssay Description:Displacement of 125I-NDP-a-MSH from human Melanocortin receptor 4 after 2 hrs by TopCount microplate scintillation and luminescence counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  2nMAssay Description:Binding affinity to human kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50141059(N-Butyloxycarbonyl-4'-(2-Ethyl-5,7-dimethyl-imidaz...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to angiotensin II receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50118336(1-(5-Fluoro-benzo[b]thiophen-3-yl)-3-(4-quinolin-8...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H] 8-OH-DPAT from rat 5-Hydroxytryptamine receptor 1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50409817(VUF-5681 | CHEMBL78498)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-NR-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50088422((2R,3R,4S,5R)-2-(6-(3-iodobenzylamino)-9H-purin-9-...)
Affinity DataKi:  5.80nMAssay Description:Binding affinity to Adenosine receptor A3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50118335(3-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazin...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H] 8-OH-DPAT from rat 5-Hydroxytryptamine receptor 1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50147749(1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]N/OFQ from human nociceptin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50138296((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataKi:  6nMAssay Description:Displacement of 125I-NDP-a-MSH from human Melanocortin receptor 4 after 2 hrs by TopCount microplate scintillation and luminescence counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM21368(CHEMBL224820 | 6-[4-(2-methoxyphenyl)piperazin-1-y...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50150942(CHEMBL3394209)
Affinity DataKi:  8.20nMAssay Description:Binding affinity to angiotensin II receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM21371(CHEMBL225512 | 6-[4-(2-hydroxyphenyl)piperazin-1-y...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50145197(CHEMBL3394207)
Affinity DataKi:  12nMAssay Description:Binding affinity to angiotensin II receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM21369(CHEMBL222755 | 6-[4-(2-methylphenyl)piperazin-1-yl...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50094079((4-Amino-2-methyl-phenyl)-(7-chloro-2,3,4,5-tetrah...)
Affinity DataIC50: 18nMAssay Description:Displacement of [3H]AVP from human Vasopressin V2 receptor expressed in HeLa cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50409216(CHEMBL150701)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-NR-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50150941(MRS-1292 | CHEMBL2181969)
Affinity DataKi:  29nMAssay Description:Binding affinity to Adenosine receptor A3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50146893(4-{(E)-2-[({[2,4-Dichloro-3-(4-ethoxy-2-methyl-qui...)
Affinity DataIC50: 34nMAssay Description:Displacement of [3H]BK from cloned human B2 bradykinin receptor expressed in CHO cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50085658(2-Cl-CPA | CHEMBL284969 | 2-chloro-N6-cyclopentyla...)
Affinity DataKi:  38nMAssay Description:Binding affinity to Adenosine receptor A3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]-NR-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataKi:  72nMAssay Description:Binding affinity to Adenosine receptor A3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50150943(CHEMBL154529)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]-NR-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataKi:  120nMAssay Description:Binding affinity to human kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50150944(CHEMBL153207)
Affinity DataKi:  182nMAssay Description:Displacement of [3H]-NR-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50147746(1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-indol-2-on...)
Affinity DataKi:  201nMAssay Description:Displacement of [3H]N/OFQ from human nociceptin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed