Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with all data for entry = 50046465
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113997(CHEMBL3605523)
Affinity DataEC50:  2.42E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114063(CHEMBL3605533)
Affinity DataEC50:  7nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114062(CHEMBL3605532)
Affinity DataEC50:  8nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114061(CHEMBL3605531)
Affinity DataEC50:  1.80E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114060(CHEMBL3605530)
Affinity DataEC50:  9.00E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114059(CHEMBL3605529)
Affinity DataEC50:  310nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114058(CHEMBL3605528)
Affinity DataEC50:  210nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114057(CHEMBL3605527)
Affinity DataEC50:  1.17E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114056(CHEMBL3605526)
Affinity DataEC50:  2.34E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114055(CHEMBL3605525)
Affinity DataEC50:  800nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113996(CHEMBL3605541)
Affinity DataEC50:  9.20E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113995(CHEMBL3605542)
Affinity DataEC50:  30nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114064(CHEMBL3605534)
Affinity DataEC50:  24nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113998(CHEMBL3605522)
Affinity DataEC50:  2.35E+4nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114001(CHEMBL3605521)
Affinity DataEC50:  190nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114002(CHEMBL3605520)
Affinity DataEC50:  5nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114012(CHEMBL3605519)
Affinity DataEC50:  180nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114017(CHEMBL3605518)
Affinity DataEC50:  130nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114018(CHEMBL3605517)
Affinity DataEC50:  1nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114051(CHEMBL3605516)
Affinity DataEC50:  5nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114052(CHEMBL3605515)
Affinity DataEC50:  9nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114053(CHEMBL3605514)
Affinity DataEC50:  50nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50069638(CHEMBL3402546)
Affinity DataEC50:  250nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114054(CHEMBL3605524)
Affinity DataEC50:  1.84E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113989(CHEMBL3605551)
Affinity DataEC50:  2.20E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113978(CHEMBL3605543)
Affinity DataEC50:  26nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114070(CHEMBL3605540)
Affinity DataEC50:  240nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114069(CHEMBL3605539)
Affinity DataEC50:  1.80E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113981(CHEMBL3605544)
Affinity DataEC50:  1.00E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113982(CHEMBL3605545)
Affinity DataEC50:  420nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113983(CHEMBL3605546)
Affinity DataEC50:  590nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113984(CHEMBL3605547)
Affinity DataEC50:  430nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113985(CHEMBL3605548)
Affinity DataEC50:  800nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113986(CHEMBL3605549)
Affinity DataEC50:  1.10E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113987(CHEMBL3605550)
Affinity DataEC50:  4.00E+3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113988(CHEMBL3603858)
Affinity DataEC50:  650nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113990(CHEMBL3605552)
Affinity DataEC50:  34nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113991(CHEMBL3605553)
Affinity DataEC50:  9nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113992(CHEMBL3605554)
Affinity DataEC50:  3nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113993(CHEMBL3605555)
Affinity DataEC50:  6nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113994(CHEMBL3605556)
Affinity DataEC50:  28nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113980(CHEMBL3605557)
Affinity DataEC50:  7nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114068(CHEMBL3605538)
Affinity DataEC50:  1.24E+4nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114067(CHEMBL3605537)
Affinity DataEC50:  57nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114066(CHEMBL3605536)
Affinity DataEC50:  27nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113979(CHEMBL3605558)
Affinity DataEC50:  4nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114065(CHEMBL3605535)
Affinity DataEC50:  12nMAssay Description:Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor transl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113978(CHEMBL3605543)
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 5 mins in presence of NADPH and specific substrates by LC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50114058(CHEMBL3605528)
Affinity DataIC50: 230nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 5 mins in presence of NADPH and specific substrates by LC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50113995(CHEMBL3605542)
Affinity DataIC50: 830nMAssay Description:Inhibition of CYP3A5 in human liver microsomes incubated for 5 mins in presence of NADPH and specific substrates by LC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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