Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50046558
TargetSodium channel protein type 1 subunit alpha [1489-1708](Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118518(CHEMBL3617066)
Affinity DataKd:  290nMAssay Description:Inhibition of mouse NaV1.1 channel by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118518(CHEMBL3617066)
Affinity DataKd:  290nMAssay Description:Inhibition of rat NaV1.7 channel by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of NaV1.2 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50: 0.0620nMAssay Description:Inhibition of NaV1.4 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of NaV1.5 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118515(CHEMBL3617062)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118512(CHEMBL3617054)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118513(CHEMBL3617065 | US10071957, Example 6)
Affinity DataIC50: 6nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118485(CHEMBL3617059)
Affinity DataIC50: 11nMAssay Description:Inhibition of human NaV1.8 channel in HEK cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118511(CHEMBL3617055)
Affinity DataIC50: 14nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 20nMAssay Description:Inhibition of human TTX-sensitive NaV1.3 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 1 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 20nMAssay Description:Inhibition of human NaV1.1 channel by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118517(CHEMBL3617067)
Affinity DataIC50: 21nMAssay Description:Inhibition of human NaV1.7 channel by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024250(CHEMBL2324000)
Affinity DataIC50: 28nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118514(US9481677, 38 | CHEMBL3617063)
Affinity DataIC50: 30nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145490(US8952169, 283)
Affinity DataIC50: 30nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118517(CHEMBL3617067)
Affinity DataIC50: 36nMAssay Description:Inhibition of rat NaV1.2 channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118492(CHEMBL3617056)
Affinity DataIC50: 90nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118518(CHEMBL3617066)
Affinity DataIC50: 90nMAssay Description:Inhibition of mouse NaV1.4 channel by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118487(CHEMBL3617057)
Affinity DataIC50: 100nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118518(CHEMBL3617066)
Affinity DataIC50: 240nMAssay Description:Inhibition of mouse NaV1.6 channel by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 240nMAssay Description:Inhibition of human NaV1.2 channel by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118482(CHEMBL3617061)
Affinity DataIC50: 251nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells treated for 120 secs by QPatch assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118484(CHEMBL3617060)
Affinity DataIC50: 251nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells treated for 120 secs by QPatch assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118517(CHEMBL3617067)
Affinity DataIC50: 375nMAssay Description:Inhibition of rat NaV1.3 channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118486(CHEMBL3617058)
Affinity DataIC50: 417nMAssay Description:Inhibition of tetrodotoxin-sensitive NaV1.8 channel in human SHSY-5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118483(CHEMBL3616483)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells treated for 120 secs by QPatch assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118513(CHEMBL3617065 | US10071957, Example 6)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.4 channel by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118515(CHEMBL3617062)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118514(US9481677, 38 | CHEMBL3617063)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.6 channel by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.8 channel by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145490(US8952169, 283)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed