Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50045853
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086213(CHEMBL3425734)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086210(CHEMBL3425739)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086214(CHEMBL3425744)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086213(CHEMBL3425734)
Affinity DataIC50: 47nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086220(CHEMBL3425735)
Affinity DataIC50: 53nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 57nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086218(CHEMBL3425740)
Affinity DataIC50: 57nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 57nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 61nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 61nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086212(CHEMBL3425737)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086219(CHEMBL3425736)
Affinity DataIC50: 87nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086210(CHEMBL3425739)
Affinity DataIC50: 88nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086218(CHEMBL3425740)
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086222(CHEMBL3425732)
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086221(CHEMBL3425733)
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086223(CHEMBL3425731)
Affinity DataIC50: 160nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086215(CHEMBL3425743 | US9260413, Example 3)
Affinity DataIC50: 170nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086217(CHEMBL3425741)
Affinity DataIC50: 180nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086214(CHEMBL3425744)
Affinity DataIC50: 200nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086217(CHEMBL3425741)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086234(CHEMBL3425721)
Affinity DataIC50: 400nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086212(CHEMBL3425737)
Affinity DataIC50: 410nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086225(CHEMBL3425729)
Affinity DataIC50: 680nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086209(CHEMBL3425722)
Affinity DataIC50: 860nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086218(CHEMBL3425740)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086215(CHEMBL3425743 | US9260413, Example 3)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant rat membrane bound COMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL using dopamine/SAM as substrate/cofactor pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086213(CHEMBL3425734)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086210(CHEMBL3425739)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086212(CHEMBL3425737)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086227(CHEMBL3425727)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086217(CHEMBL3425741)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086233(CHEMBL3425723)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086220(CHEMBL3425735)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086228(CHEMBL3425726)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086219(CHEMBL3425736)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086230(CHEMBL3425725)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086231(CHEMBL3425513)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086215(CHEMBL3425743 | US9260413, Example 3)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086224(CHEMBL3425730)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086226(CHEMBL3425728)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086232(CHEMBL3425724)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086216(CHEMBL3425742)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086229(CHEMBL326815)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50086216(CHEMBL3425742)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed