Compile Data Set for Download or QSAR
Report error Found 94 Enz. Inhib. hit(s) with all data for entry = 50001664
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017103(9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenyli...)
Affinity DataIC50: 400nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017103(9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenyli...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017102(CHEMBL35048 | 4-(3-Butoxy-4-methoxy-phenyl)-pyrrol...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017109(CHEMBL36290 | N-Butyl-4-[2-methoxy-5-(5-oxo-pyrrol...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017107(CHEMBL289011 | 1-Benzyl-4-(3,4-dimethoxy-phenyl)-p...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017092(CHEMBL416770 | 4-(3-Isobutoxy-4-methoxy-phenyl)-py...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017113(CHEMBL284845 | 4-(3,4-Dimethoxy-phenyl)-1-phenyl-p...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017108(CHEMBL36182 | 4-(3,4-Dimethoxy-phenyl)-2-oxo-pyrro...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017093(CHEMBL285663 | 4-(3,4-Dimethoxy-phenyl)-3-methyl-p...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017114(CHEMBL439920 | 4-[4-Methoxy-3-(2-methyl-allyloxy)-...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017112(CHEMBL32727 | 1-Acetyl-4-(3,4-dimethoxy-phenyl)-py...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50010981(4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one |...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017117(CHEMBL288553 | 4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017118(CHEMBL32139 | 4-(3-Allyloxy-4-methoxy-phenyl)-pyrr...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017111(CHEMBL35393 | 4-(3,4-Dimethoxy-phenyl)-1-methyl-py...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017120(CHEMBL284512 | N-Cyclohexyl-4-[2-methoxy-5-(5-oxo-...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017115(CHEMBL32155 | 4-[4-Methoxy-3-(2-methyl-butoxy)-phe...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017099(CHEMBL9175 | 4-(3,4-Dimethoxy-phenyl)-pyrrolidin-2...)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017097(CHEMBL287311 | 1-Benzoyl-4-(3,4-dimethoxy-phenyl)-...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017096(CHEMBL289253 | 4-(3-Benzyloxy-4-methoxy-phenyl)-py...)
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017101(CHEMBL35053 | 7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydr...)
Affinity DataIC50: 1.38E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017096(CHEMBL289253 | 4-(3-Benzyloxy-4-methoxy-phenyl)-py...)
Affinity DataIC50: 1.74E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017094(CHEMBL35893 | 4-(3-Butoxy-4-methoxy-phenyl)-pyrrol...)
Affinity DataIC50: 1.95E+5nMAssay Description:Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017115(CHEMBL32155 | 4-[4-Methoxy-3-(2-methyl-butoxy)-phe...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017104(CHEMBL32807 | 7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydr...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 2.46E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50010981(4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one |...)
Affinity DataIC50: 3.80E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017095(CHEMBL35958 | 4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-y...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017094(CHEMBL35893 | 4-(3-Butoxy-4-methoxy-phenyl)-pyrrol...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017116(CHEMBL36196 | 5,6-Dimethoxy-3,3a,8,8a-tetrahydro-1...)
Affinity DataIC50: 8.00E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50010981(4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one |...)
Affinity DataIC50: 9.40E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017120(CHEMBL284512 | N-Cyclohexyl-4-[2-methoxy-5-(5-oxo-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017095(CHEMBL35958 | 4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-y...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017099(CHEMBL9175 | 4-(3,4-Dimethoxy-phenyl)-pyrrolidin-2...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017105(CHEMBL35392 | 4-(3,4-Dimethoxy-phenyl)-2-oxo-pyrro...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against cAMP phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017110(CHEMBL284399 | 4-(4-Butoxy-3-methoxy-phenyl)-pyrro...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017121(CHEMBL32597 | 4-(4-Butoxy-phenyl)-pyrrolidin-2-one)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of cAMP-PDE phosphodiesterase from bovine aorta using 1 uM cAMP (insignificant)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017111(CHEMBL35393 | 4-(3,4-Dimethoxy-phenyl)-1-methyl-py...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against cAMP phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017101(CHEMBL35053 | 7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of phosphodiesterase from bovine aorta with 1 uM cGMP calcium (10 uM) and calmodulin (15 nM) (insignificant)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017098(CHEMBL36187 | 3-(3,4-Dimethoxy-phenyl)-pyrrolidine...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of cAMP-PDE phosphodiesterase from bovine aorta using 1 uM cAMP (insignificant)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017121(CHEMBL32597 | 4-(4-Butoxy-phenyl)-pyrrolidin-2-one)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against cAMP phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017108(CHEMBL36182 | 4-(3,4-Dimethoxy-phenyl)-2-oxo-pyrro...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against cAMP phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017096(CHEMBL289253 | 4-(3-Benzyloxy-4-methoxy-phenyl)-py...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017105(CHEMBL35392 | 4-(3,4-Dimethoxy-phenyl)-2-oxo-pyrro...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of cAMP-PDE phosphodiesterase from bovine aorta using 1 uM cAMP (insignificant)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017104(CHEMBL32807 | 7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against cAMP phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017118(CHEMBL32139 | 4-(3-Allyloxy-4-methoxy-phenyl)-pyrr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017098(CHEMBL36187 | 3-(3,4-Dimethoxy-phenyl)-pyrrolidine...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against cAMP phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017106(CHEMBL286419 | 4-Phenyl-pyrrolidin-2-one)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017109(CHEMBL36290 | N-Butyl-4-[2-methoxy-5-(5-oxo-pyrrol...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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